INT128363

Context Info Confidence 0.50 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.53 Pain Relevance 0.52

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)

Anatomy Link Frequency neutrophil 6 joint 2 Ltb4r1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 20 99.26 Inflammatory mediators 3 90.24 Inflammatory response 3 86.48 cINOD 3 72.80 antagonist 9 71.76 Pain 1 56.64 cytokine 8 25.00 withdrawal 3 14.08 corticosteroid 38 12.24 cva 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 30 99.26 Asthma 78 96.68 Syndrome 189 95.40 Peritonitis 6 95.16 Infection 5 86.40 Drug Hypersensitivity 1 75.60 Nociception 1 75.00 Arthritis 1 59.84 Hypersensitivity 8 59.32 Pain 1 56.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The production of LTB4 induced by zymosan in the joint was reduced by the pretreatment with fucoidan or antineutrophil antibody as well as the production of PGE2 induced by LTB4.

Negative_regulation (reduced) of Gene_expression (production) of LTB4 in joint

1) Confidence 0.50 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.32 Pain Relevance 0.19

Altogether, the results suggest that SGE has anti-inflammatory properties that are associated with inhibition of TNF-alpha and LTB4 production and/or with the neutrophil chemotactic activity of LTB4.

Negative_regulation (inhibition) of Gene_expression (production) of LTB4 in neutrophil associated with inflammation

2) Confidence 0.23 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.49 Pain Relevance 0.21

The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.

Negative_regulation (inhibited) of Gene_expression (production) of leukotriene B4 in neutrophil

3) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.38 Pain Relevance 0.06

The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.

Negative_regulation (inhibited) of Gene_expression (production) of LTB4 in neutrophil

4) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.38 Pain Relevance 0.06

Zileuton, is a 5-LO inhibitor and thus inhibits the synthesis of LTB4 in addition to the cysLTs.

Negative_regulation (inhibits) of Gene_expression (synthesis) of LTB4

5) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.96 Pain Relevance 0

General Comments

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