INT128363

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.53
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
neutrophil 6
joint 2
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 99.26 Very High Very High Very High
Inflammatory mediators 3 90.24 High High
Inflammatory response 3 86.48 High High
cINOD 3 72.80 Quite High
antagonist 9 71.76 Quite High
Pain 1 56.64 Quite High
cytokine 8 25.00 Low Low
withdrawal 3 14.08 Low Low
corticosteroid 38 12.24 Low Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 99.26 Very High Very High Very High
Asthma 78 96.68 Very High Very High Very High
Syndrome 189 95.40 Very High Very High Very High
Peritonitis 6 95.16 Very High Very High Very High
Infection 5 86.40 High High
Drug Hypersensitivity 1 75.60 Quite High
Nociception 1 75.00 Quite High
Arthritis 1 59.84 Quite High
Hypersensitivity 8 59.32 Quite High
Pain 1 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of LTB4 induced by zymosan in the joint was reduced by the pretreatment with fucoidan or antineutrophil antibody as well as the production of PGE2 induced by LTB4.
Negative_regulation (reduced) of Gene_expression (production) of LTB4 in joint
1) Confidence 0.50 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.32 Pain Relevance 0.19
Altogether, the results suggest that SGE has anti-inflammatory properties that are associated with inhibition of TNF-alpha and LTB4 production and/or with the neutrophil chemotactic activity of LTB4.
Negative_regulation (inhibition) of Gene_expression (production) of LTB4 in neutrophil associated with inflammation
2) Confidence 0.23 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.49 Pain Relevance 0.21
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Negative_regulation (inhibited) of Gene_expression (production) of leukotriene B4 in neutrophil
3) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.38 Pain Relevance 0.06
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Negative_regulation (inhibited) of Gene_expression (production) of LTB4 in neutrophil
4) Confidence 0.17 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.38 Pain Relevance 0.06
Zileuton, is a 5-LO inhibitor and thus inhibits the synthesis of LTB4 in addition to the cysLTs.
Negative_regulation (inhibits) of Gene_expression (synthesis) of LTB4
5) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.96 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox