INT128364

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 23.96
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
macrophages 2
T cells 2
Kupffer cell 1
SCN 1
immune cell 1
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 369 100.00 Very High Very High Very High
Inflammation 278 100.00 Very High Very High Very High
cytokine 62 100.00 Very High Very High Very High
ischemia 20 99.98 Very High Very High Very High
Sciatic nerve 15 99.68 Very High Very High Very High
Multiple sclerosis 240 99.40 Very High Very High Very High
antagonist 32 99.34 Very High Very High Very High
Angina 20 99.28 Very High Very High Very High
Thermal hyperalgesia 9 99.04 Very High Very High Very High
Brush evoked pain 9 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 289 100.00 Very High Very High Very High
Injury 2 100.00 Very High Very High Very High
Coronary Artery Disease 10 99.98 Very High Very High Very High
Myocardial Infarction 25 99.84 Very High Very High Very High
Acute Coronary Syndrome 15 99.68 Very High Very High Very High
Demyelinating Disease 312 99.40 Very High Very High Very High
Cv General 3 Under Development 20 99.28 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 99.16 Very High Very High Very High
Infection 181 99.12 Very High Very High Very High
Hyperalgesia 9 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL3 levels are elevated during ACS and released upon ischemia.
Positive_regulation (elevated) of CCL3 associated with ischemia
1) Confidence 0.70 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.27 Pain Relevance 0.53
CCL3 levels were significantly elevated in AMI vs. controls (P=0.02) albeit, that adjustment for confounding factors attenuated this association.
Positive_regulation (elevated) of CCL3 associated with myocardial infarction
2) Confidence 0.70 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.46 Pain Relevance 0.68
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of MIP-1alpha in Kupffer cell associated with chemokine, inflammation and cytokine
3) Confidence 0.67 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.55 Pain Relevance 0.70
CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events.
Positive_regulation (elevated) of MIP-1 alpha associated with acute coronary syndrome
4) Confidence 0.67 Published 2008 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 18619972 Disease Relevance 1.33 Pain Relevance 0.58
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Ccl3 in immune cell associated with chemokine, injury and infection
5) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.51 Pain Relevance 0.26
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Ccl3 associated with chemokine
6) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.89 Pain Relevance 0.62
Moreover, co-incubation of LTB4 (but not fMLP, TNF-alpha and MIP-1alpha) with SGE inhibited the ability of LTB4 to induce neutrophil migration in vivo and in vitro.
Positive_regulation (co-incubation) of MIP-1alpha in neutrophil
7) Confidence 0.49 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.46 Pain Relevance 0.17
In support of a direct association with cardiac ischemia CCL3 levels were also seen to be elevated in patients with UAP at baseline and significantly down-regulated after 180 days (P<0.001).
Positive_regulation (elevated) of CCL3 associated with angina, coronary artery disease and ischemia
8) Confidence 0.47 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.42 Pain Relevance 0.68
CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events.
Positive_regulation (elevated) of CCL3 associated with acute coronary syndrome
9) Confidence 0.47 Published 2008 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 18619972 Disease Relevance 1.33 Pain Relevance 0.58
We have previously shown that CCL3 is significantly upregulated both during primary murine RSV infection [12], [13] and in enhanced immunopathology after antigenic sensitization [14].
Positive_regulation (upregulated) of CCL3 associated with infection and respiratory syncytial virus
10) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 2.13 Pain Relevance 0.18
MIP-1alpha mRNA and its protein were dramatically up-regulated after PSL, and MIP-1alpha was localized on macrophages and Schwann cells in the injured sciatic nerve (SCN).
Positive_regulation (up-regulated) of MIP-1alpha in SCN associated with sciatic nerve
11) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.79 Pain Relevance 0.85
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Positive_regulation (up-regulated) of MIP-1alpha in macrophages associated with sciatic nerve
12) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.00 Pain Relevance 1.10
Pathogenicity was associated with T cell production of the macrophage-attracting chemokines CCL3 and CCL4 when T cells were primed with APCs expressing both B7-1 and ICAM-1 [113].
Positive_regulation (chemokines) of CCL3 in T cells associated with chemokine
13) Confidence 0.33 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.92 Pain Relevance 0.29
, Il-6, IL-12, CCL2 and CCL3 increased within 24 hours of CL, but not PBS treatment, prior to virus infection.
Positive_regulation (increased) of CCL3 associated with infection
14) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.18 Pain Relevance 0.39
The increase of CCL3 and CCL5 in the CSF during a relapse correlates with the increase in the expression of their receptor, CCR5 on TH1 lymphocytes, which results in an enhanced migratory activity of these cells towards CCL3 and CCL5.
Positive_regulation (increase) of CCL3 in lymphocytes associated with recurrence
15) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.81 Pain Relevance 0.29
CCR1 antagonist compounds were shown to inhibit CCL3 and CCL5 induced migration of MNCs in a dose dependent manner, and to reduce clinical EAE in rat [36-38].
Positive_regulation (induced) of CCL3 associated with multiple sclerosis and antagonist
16) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.39 Pain Relevance 0.37
Amongst CC chemokines, CCL3 and CCL5 were most consistently found to be elevated in the CSF of MS patients during relapses as compared to normal controls [59-61].
Positive_regulation (elevated) of CCL3 associated with chemokine, multiple sclerosis and recurrence
17) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.88 Pain Relevance 0.45
These T cells showed an increased migration towards CCL3 and CCL5, suggesting a functional significance of the altered receptor expression [42,52].
Positive_regulation (increased) of CCL3 in T cells
18) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.75 Pain Relevance 0.26
The beta-chemokines CCL5/regulated upon activation, normal T cell expressed and secreted, CCL3/macrophage inflammatory protein-1alpha, and CCL4/macrophage inflammatory protein-1beta were increased by 12-h exposure to HIV-1 Tat.
Positive_regulation (increased) of CCL3 in macrophage associated with chemokine, inflammation and acquired immune deficiency syndrome or hiv infection
19) Confidence 0.20 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20403075 Disease Relevance 0.88 Pain Relevance 0.58
MIP-1alpha receptors (CCR1 and CCR5) mRNA and their proteins were also up-regulated in the SCN after PSL, and were localized on macrophages and Schwann cells.
Positive_regulation (up-regulated) of MIP-1alpha in Schwann cells associated with sciatic nerve
20) Confidence 0.15 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 1.00 Pain Relevance 1.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox