INT128365

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.04
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
joint 6
neutrophil 6
respiratory 4
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 176 99.80 Very High Very High Very High
chemokine 20 98.80 Very High Very High Very High
fibrosis 5 97.24 Very High Very High Very High
Inflammation 266 95.44 Very High Very High Very High
antagonist 30 92.40 High High
Central nervous system 18 86.48 High High
Inflammatory response 25 83.92 Quite High
corticosteroid 29 82.32 Quite High
Pain 5 71.00 Quite High
cerebral cortex 8 50.16 Quite High
Disease Link Frequency Relevance Heat
Arthritis 187 99.80 Very High Very High Very High
Pulmonary Disease 218 99.46 Very High Very High Very High
Adult Respiratory Distress Syndrome 4 98.50 Very High Very High Very High
Disease 131 98.48 Very High Very High Very High
Pulmonary Fibrosis 2 97.24 Very High Very High Very High
Rhinitis 9 96.52 Very High Very High Very High
Asthma 81 95.98 Very High Very High Very High
Peritonitis 2 95.48 Very High Very High Very High
INFLAMMATION 303 95.44 Very High Very High Very High
Hypersensitivity 15 95.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of LTB4 induced by zymosan in the joint was reduced by the pretreatment with fucoidan or antineutrophil antibody as well as the production of PGE2 induced by LTB4.
Positive_regulation (induced) of Gene_expression (production) of LTB4 in joint
1) Confidence 0.60 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.32 Pain Relevance 0.19
Furthermore, zymosan induced an increase in joint LTB4 production.
Positive_regulation (increase) of Gene_expression (production) of LTB4 in joint
2) Confidence 0.40 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.38 Pain Relevance 0.23
Furthermore, zymosan induced an increase in joint LTB4 production.
Positive_regulation (induced) of Gene_expression (production) of LTB4 in joint
3) Confidence 0.40 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.38 Pain Relevance 0.23
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Positive_regulation (required) of in neutrophil Gene_expression (expression) of BLT1 in neutrophils associated with chemokine and arthritis
4) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.63 Pain Relevance 0.35
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Positive_regulation (required) of in neutrophil Gene_expression (expression) of leukotriene B4 receptor in neutrophils associated with chemokine and arthritis
5) Confidence 0.34 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.63 Pain Relevance 0.35
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Positive_regulation (induced) of Gene_expression (production) of leukotriene B4 in neutrophil
6) Confidence 0.27 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.32 Pain Relevance 0.03
g/day of inhaled fluticasone at a constant dose for at least 8 weeks had higher exhaled LTB4 values than those who were receiving with 200 ?
Positive_regulation (exhaled) of Gene_expression (values) of LTB4
7) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.64 Pain Relevance 0.04
Since LTB4 is synthesized by 5?
Positive_regulation (Since) of Gene_expression (synthesized) of LTB4
8) Confidence 0.10 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.88 Pain Relevance 0.22
Various airway allergic and inflammatory diseases, including asthma [12-15], allergic rhinitis [16], idiopathic pulmonary fibrosis [17], acute lung injury or adult respiratory distress syndrome [18], and chronic obstructive pulmonary disease [19], are associated with increased levels of LTB4 and/or BLT1 expression.
Positive_regulation (increased) of Gene_expression (expression) of BLT1 in respiratory associated with pulmonary disease, hypersensitivity, adult respiratory distress syndrome, pulmonary fibrosis, disease, fibrosis, asthma, rhinitis and inflammation
9) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 1.37 Pain Relevance 0.42
Various airway allergic and inflammatory diseases, including asthma [12-15], allergic rhinitis [16], idiopathic pulmonary fibrosis [17], acute lung injury or adult respiratory distress syndrome [18], and chronic obstructive pulmonary disease [19], are associated with increased levels of LTB4 and/or BLT1 expression.
Positive_regulation (levels) of Gene_expression (expression) of BLT1 in respiratory associated with pulmonary disease, hypersensitivity, adult respiratory distress syndrome, pulmonary fibrosis, disease, fibrosis, asthma, rhinitis and inflammation
10) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2834663 Disease Relevance 1.37 Pain Relevance 0.42
Following LPS treatment for 24 h, IL-8, PGE2 and LTB4 levels increased in a LPS dose-dependent manner (0.1 to 10 ?
Positive_regulation (increased) of Gene_expression (levels) of LTB4
11) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.12 Pain Relevance 0.04

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