INT12837

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 57
Total Number 57
Disease Relevance 5.31
Pain Relevance 15.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
brain 3
SH-SY5Y 1
striatum 1
neuronal 1
Gonadal 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 77 100.00 Very High Very High Very High
Kappa opioid receptor 4 100.00 Very High Very High Very High
Delta opioid receptors 1 100.00 Very High Very High Very High
agonist 26 99.98 Very High Very High Very High
antagonist 45 99.96 Very High Very High Very High
Dopamine 10 99.76 Very High Very High Very High
antidepressant 9 99.72 Very High Very High Very High
narcan 6 99.66 Very High Very High Very High
nalbuphine 7 99.64 Very High Very High Very High
Morphine 8 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 4 99.92 Very High Very High Very High
Schizophrenia 67 99.60 Very High Very High Very High
Apoptosis 8 99.48 Very High Very High Very High
Toxicity 1 98.60 Very High Very High Very High
Prostate Cancer 5 98.44 Very High Very High Very High
Stress 4 98.30 Very High Very High Very High
Rheumatoid Arthritis 97 97.24 Very High Very High Very High
Neuroblastoma 1 96.40 Very High Very High Very High
Osteoarthritis 190 94.08 High High
Disorders Of The Lacrimal System 4 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of sigma receptor ligands and their effects on muscarine-induced Ca(2+) changes in SH-SY5Y cells.
sigma receptor Binding (Binding) of in SH-SY5Y associated with fortral
1) Confidence 0.48 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 11834244 Disease Relevance 0.10 Pain Relevance 0.67
Interactions between U-50,488H and sigma receptor antagonists: EEG, EEG power spectral and behavioral correlates.
sigma receptor Binding (Interactions) of associated with antagonist
2) Confidence 0.46 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8095467 Disease Relevance 0.40 Pain Relevance 0.22
Moreover, the dysphoria and psychotomimetic effects produced by racemic cyclazocine and MR 2034 are antagonized dramatically by naloxone, which is levorotatory and has no affinity for the sigma receptor as currently defined.
sigma receptor Neg (no) Binding (affinity) of associated with narcan
3) Confidence 0.45 Published 1990 Journal Neuropsychopharmacology Section Abstract Doc Link 2163646 Disease Relevance 0 Pain Relevance 0.80
The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.
sigma1 receptor Binding (interacts) of associated with fortral
4) Confidence 0.42 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.22
The sigma1 receptor is distinguished for its ability to bind various pharmacological agents including drugs of abuse such as cocaine and methamphetamine.
sigma1 receptor Binding (bind) of associated with cocaine
5) Confidence 0.42 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.05
Interestingly, the well studied sphingolipid mediator sphingosine-1 phosphate did not bind to the sigma1 or the sigma2 receptor.
sigma2 receptor Neg (not) Binding (bind) of
6) Confidence 0.42 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.13
[Neuropharmacological effects of sigma receptor ligands: anxiolytic, anti-amnesic and neuroprotective effects].
sigma receptor Binding (ligands) of associated with anxiety disorder
7) Confidence 0.36 Published 1996 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Title Doc Link 8905794 Disease Relevance 0.19 Pain Relevance 0.09
Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.


SIGMAR1 Neg (no) Binding (association) of associated with schizophrenia
8) Confidence 0.35 Published 2003 Journal BMC Psychiatry Section Abstract Doc Link PMC270036 Disease Relevance 0.65 Pain Relevance 0
Table 2 showed comparison among the present study and the two previous studies of case-control association with the SIGMAR1 gene.
SIGMAR1 Binding (association) of
9) Confidence 0.35 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC270036 Disease Relevance 0.08 Pain Relevance 0
The selective binding of sphingosine but not sphingosine-1 phosphate to the sigma1 receptor suggests a mechanism for regulation of sigma1 receptor activity by the sphingosine kinase.
sigma1 receptor Neg (not) Binding (binding) of
10) Confidence 0.33 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.12
We have performed molecular modeling studies on several sigma 1 specific ligands, including PD144418, spipethiane, haloperidol, pentazocine, and others to develop a pharmacophore for sigma 1 receptor-ligand binding, under the assumption that all the compounds interact at the same receptor binding site.
sigma 1 Binding (binding) of associated with fortral
11) Confidence 0.33 Published 2004 Journal J. Mol. Graph. Model. Section Abstract Doc Link 14629980 Disease Relevance 0 Pain Relevance 0.10
We found that long alkyl chain primary amines including endogenous amines belonging to the sphingolipid family such as D-erythro-sphingosine and sphinganine bind with considerable affinity to the sigma1 receptor but not to the sigma2 receptor.
sigma2 receptor Binding (bind) of
12) Confidence 0.32 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.13
We found that long alkyl chain primary amines including endogenous amines belonging to the sphingolipid family such as D-erythro-sphingosine and sphinganine bind with considerable affinity to the sigma1 receptor but not to the sigma2 receptor.
sigma1 receptor Binding (bind) of
13) Confidence 0.32 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.13
The binding of D-erythro-sphingosine to the sigma1 receptor appears to be competitive in nature as assessed against the radioligand [3H]-(+)-pentazocine.
sigma1 receptor Binding (binding) of associated with fortral
14) Confidence 0.32 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.14
Because of multireceptors present in acini, their agonist or antagonist behaviour could not be attributed solely to interaction with the sigma-receptor unless specific antagonists were added.
sigma-receptor Binding (interaction) of associated with antagonist and agonist
15) Confidence 0.31 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614245 Disease Relevance 0.07 Pain Relevance 0.65
Scatchard plot analysis revealed Kd values of 7.1 nM and 0.15 nM for (+)-pentazocine and SR 31747A, respectively, indicating an affinity of SR-BP 50-fold higher for SR 31747A than for pentazocine.
SR-BP Binding (affinity) of associated with fortral
16) Confidence 0.30 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341151 Disease Relevance 0 Pain Relevance 0.38
These results demonstrate the potential use of sigma receptor binding ligands in non-invasive diagnostic imaging of prostate cancer and its treatment.
sigma receptor Binding (ligands) of associated with prostate cancer and imagery
17) Confidence 0.30 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10493511 Disease Relevance 0.40 Pain Relevance 0.11
Pentazocine binds only to sigma1 receptors.
sigma1 Binding (binds) of associated with fortral
18) Confidence 0.30 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.06 Pain Relevance 0.47
In vitro and in vivo characterisation of [3H]ANSTO-14 binding to the sigma 1 binding sites.
sigma 1 Binding (binding) of
19) Confidence 0.30 Published 1999 Journal Nucl. Med. Biol. Section Title Doc Link 10100221 Disease Relevance 0 Pain Relevance 0.10
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
sigma1 receptor Binding (interactions) of associated with fortral and dopamine
20) Confidence 0.29 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 17961544 Disease Relevance 0.25 Pain Relevance 0.29

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