INT128376

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 14.24
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
stem 2
tube 1
bone marrow 1
islets of Langerhans 1
posterior 1
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 7 95.44 Very High Very High Very High
abdominal pain 12 78.16 Quite High
Bioavailability 4 75.00 Quite High
Central nervous system 24 72.08 Quite High
Pain 3 70.24 Quite High
corticosteroid 2 61.72 Quite High
cINOD 2 61.04 Quite High
Inflammation 45 50.00 Quite Low
cytokine 32 41.04 Quite Low
dexamethasone 2 30.32 Quite Low
Disease Link Frequency Relevance Heat
Cancer 452 99.90 Very High Very High Very High
Glioma 1 98.14 Very High Very High Very High
Gastrointestinal Stromal Tumor 352 97.80 Very High Very High Very High
Necrosis 9 97.28 Very High Very High Very High
Neuroendocrine Cancer 30 96.72 Very High Very High Very High
Hyperplasia 6 96.64 Very High Very High Very High
Synovial Sarcoma 1 96.48 Very High Very High Very High
Lung Cancer 3 95.76 Very High Very High Very High
Dyspepsia 7 95.44 Very High Very High Very High
Neurilemmoma 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This approach provided optimum maintenance of ultrastructural features with significant binding of antibody to the Kit receptor.
Kit receptor Binding (binding) of
1) Confidence 0.48 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17244170 Disease Relevance 0 Pain Relevance 0
It specifically targets the c-kit (CD117) proto-oncogene gain of function mutation characterising GISTs, blocking the c-kit kinase, leading to growth cessation and significant durable clinical remissions.
CD117 Binding (targets) of
2) Confidence 0.37 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.74 Pain Relevance 0.04
It specifically targets the c-kit (CD117) proto-oncogene gain of function mutation characterising GISTs, blocking the c-kit kinase, leading to growth cessation and significant durable clinical remissions.
kit Binding (targets) of
3) Confidence 0.37 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.73 Pain Relevance 0.04
In human gliomas c-kit is widely expressed and an autocrine pathway of tumor activation and progression by c-kit and its ligand has been suggested herein [17].
kit Binding (ligand) of associated with cancer and glioma
4) Confidence 0.37 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.86 Pain Relevance 0
A typical feature of virtually all GISTs is a positivity at immunohistochemistry for the KIT protein (CD117), a transmembrane receptor linked to an intracytoplasmatic tyrosine kinase [9].
KIT protein Binding (linked) of
5) Confidence 0.36 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567321 Disease Relevance 0.53 Pain Relevance 0
A typical feature of virtually all GISTs is a positivity at immunohistochemistry for the KIT protein (CD117), a transmembrane receptor linked to an intracytoplasmatic tyrosine kinase [9].
CD117 Binding (linked) of
6) Confidence 0.36 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567321 Disease Relevance 0.53 Pain Relevance 0
Immunohistochemical examination revealed reactivity to c-KIT and CD34, consistent with the diagnostic criteria for GIST, with low mitotic activity (< 5/50 HPF).
c-KIT Binding (reactivity) of associated with gastrointestinal stromal tumor
7) Confidence 0.36 Published 2009 Journal Tumori Section Abstract Doc Link 19579871 Disease Relevance 1.38 Pain Relevance 0.08
Imatinib is a selective tyrosine kinase inhibitor which binds KIT, Bcr-Abl, PDGFA/PDGFB.
KIT Binding (binds) of
8) Confidence 0.36 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 0.90 Pain Relevance 0
GISTs can be recognized by their morphology (spindle cell or epithelioid), positivity for CD117 (about 95%) and to some extent their positivity for CD34 (about 70%) [1-3].
CD117 Binding (recognized) of
9) Confidence 0.34 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567321 Disease Relevance 1.28 Pain Relevance 0
SCF/c-kit interaction plays a very important role in the development, function, and survival of rodent islets of Langerhans [14, 15].
c-kit Binding (interaction) of in islets of Langerhans
10) Confidence 0.30 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
SCs produce SCF or c-kit ligand that binds to and activates the transmembrane tyrosine kinase receptor c-kit.
c-kit Binding (binds) of
11) Confidence 0.30 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Imatinib occupies the ATP-binding pocket of KIT, preventing substrate phosphorylation which in turn inhibits downstream signaling, cellular proliferation and cell survival (Figure 1).
KIT Binding (binding) of associated with hyperplasia
12) Confidence 0.30 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.01 Pain Relevance 0.04
The appearance, number and location of the cells that we identified by staining for unphosphorylated connexin 43 and c-kit correspond most probably with MICs.
c-kit Binding (staining) of
13) Confidence 0.25 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
For flow cytometry analysis the cells were detached with 0.05% trypsin/EDTA and washed with PBS. 1 × 105 cells per tube were blocked for 5 minutes with human AB serum (Sigma) and stained for 15 minutes incubated in an ice bath in the dark with direct PE or FITC conjugated mouse anti-human monoclonal antibodies (Becton Dickinson) recognizing CD11b, CD34, CD38, CD44, CD45, CD73, CD90, CD117 and HLA-DR.
CD117 Binding (recognizing) of in tube
14) Confidence 0.24 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
SCs produce SCF or c-kit ligand that binds to and activates the transmembrane tyrosine kinase receptor c-kit.
c-kit Binding (binds) of
15) Confidence 0.23 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
For instance, McGuckin et al. demonstrated the presence of embryonic stem (ES)-like cells in CB, from which under expansion with thrombopoietin, flt-3, and c-kit ligand, slow-dividing adherent cell populations resulted with neuroglial progenitor morphology, upregulation of primitive neuroglial cell markers, and expression of glial fibrillary acidic protein (GFAP) [26].
c-kit Binding (expansion) of in stem
16) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.
CD117 Binding (negative) of
17) Confidence 0.22 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.76 Pain Relevance 0.07
In bone marrow, Stem Cell Factor/c-kit interactions form a critical component of stromal-driven differentiation of several hematopoietic lineages [73].
c-kit Binding (interactions) of in Stem
18) Confidence 0.15 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.06 Pain Relevance 0
The tumor was negative for desmin, S-100, CD 34 and c-kit (CD117) but focally positive for actin on immunohistochemistry (IHC).
c-kit Binding (negative) of associated with cancer
19) Confidence 0.13 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC546237 Disease Relevance 0.95 Pain Relevance 0
The tumor was negative for desmin, S-100, CD 34 and c-kit (CD117) but focally positive for actin on immunohistochemistry (IHC).
CD117 Binding (negative) of associated with cancer
20) Confidence 0.13 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC546237 Disease Relevance 0.95 Pain Relevance 0

General Comments

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