INT12838

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 3.52
Pain Relevance 6.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
Anatomy Link Frequency
small intestine 2
spinal cord dorsal horn 2
reticulum 2
plasma 1
liver 1
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 42 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
imagery 2 100.00 Very High Very High Very High
Immobilon 14 99.80 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
psoriasis 1 99.08 Very High Very High Very High
Nerve growth factor 8 98.60 Very High Very High Very High
Crohn's disease 1 98.56 Very High Very High Very High
agonist 43 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 12 99.84 Very High Very High Very High
Glioma 3 99.72 Very High Very High Very High
Neuroblastoma 10 99.64 Very High Very High Very High
Psoriasis 1 99.08 Very High Very High Very High
Disease 1 98.56 Very High Very High Very High
Rheumatoid Arthritis 1 97.88 Very High Very High Very High
INFLAMMATION 4 95.56 Very High Very High Very High
Drug Dependence 4 91.84 High High
Depression 12 91.00 High High
Schizophrenia 16 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of [3H]progesterone, a putative endogenous ligand to sigma-R1, to the Jurkat cell sigma-receptor could be directly demonstrated by using heterologously expressed sigma-R1 cDNA.
Gene_expression (expressed) of sigma-R1
1) Confidence 0.78 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087012 Disease Relevance 0 Pain Relevance 0.09
Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
Gene_expression (expressed) of Sigma-1 associated with fortral and cancer
2) Confidence 0.78 Published 1995 Journal Cancer Res. Section Title Doc Link 7812973 Disease Relevance 0.91 Pain Relevance 0.46
Both endogenously expressing sigma-1 receptors and transfected C-terminally enhanced yellow fluorescent protein (EYFP)-tagged sigma-1 receptors (Sig-1R-EYFP) target unique "ring-like" structures associated with endoplasmic reticulum reticular networks in NG108-15 cells.
Gene_expression (expressing) of Sig-1R in NG108-15
3) Confidence 0.75 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12730355 Disease Relevance 0.27 Pain Relevance 0.14
Northern blot analysis of SR-BP gene expression revealed a single transcript of 2 kilobases which was widely expressed among organs, with the highest abundance in liver and the lowest abundance in brain.
Gene_expression (expression) of SR-BP in liver
4) Confidence 0.75 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341151 Disease Relevance 0 Pain Relevance 0.06
When studying the binding of SR 31747A on membranes from yeast expressing SR-BP, we found a pharmacological profile of sigma 1 receptors; binding was displaced by (+)-pentazocine, haloperidol, and (+)-SKF 10,047, with (+)-SKF 10, 047 being a more potent competitor than (-)-SKF 10,047.
Gene_expression (expressing) of SR-BP associated with fortral
5) Confidence 0.75 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341151 Disease Relevance 0 Pain Relevance 0.31
We have successfully reconstituted this hypothetical model in HEK-293 cells overexpressing both the sigma1 receptor and sphingosine kinase-1.
Gene_expression (overexpressing) of sigma1 receptor
6) Confidence 0.69 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285059 Disease Relevance 0 Pain Relevance 0.10
Northern analysis and reverse transcription-polymerase chain reaction provided evidence for the expression of the recently cloned type 1 sigma-receptor (sigma-R1) in Jurkat cells.
Gene_expression (expression) of sigma-R1
7) Confidence 0.68 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087012 Disease Relevance 0 Pain Relevance 0.08
Northern analysis and reverse transcription-polymerase chain reaction provided evidence for the expression of the recently cloned type 1 sigma-receptor (sigma-R1) in Jurkat cells.
Gene_expression (expression) of sigma-receptor
8) Confidence 0.68 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087012 Disease Relevance 0 Pain Relevance 0.08
Reverse transcription-polymerase chain reaction also produced evidence for the existence of an alternatively spliced sigma-R1 variant in Jurkat cells.
Gene_expression (produced) of sigma-R1 variant
9) Confidence 0.60 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087012 Disease Relevance 0 Pain Relevance 0.08
Two types of sigma receptor exist, the sigma-1 receptor and the sigma-2 receptor. sigma-1 receptors have been cloned and their distribution, physiological functions and roles in signal transduction were recently characterised.
Gene_expression (exist) of sigma-1 receptor
10) Confidence 0.58 Published 2004 Journal CNS Drugs Section Abstract Doc Link 15089113 Disease Relevance 0 Pain Relevance 0.29
Two types of sigma receptor exist, the sigma-1 receptor and the sigma-2 receptor. sigma-1 receptors have been cloned and their distribution, physiological functions and roles in signal transduction were recently characterised.
Gene_expression (exist) of sigma receptor
11) Confidence 0.58 Published 2004 Journal CNS Drugs Section Abstract Doc Link 15089113 Disease Relevance 0 Pain Relevance 0.29
To establish the activity of sigma ligands at sigma1 and sigma2 receptor, we chose two tumour cell lines, the human SK-N-SH neuroblastoma and the rat C6 glioma lines, which express sigma2 receptors at a high density and sigma1 receptors in their high-affinity or low-affinity state.
Gene_expression (express) of sigma1 in SK-N-SH associated with neuroblastoma, cancer and glioma
12) Confidence 0.55 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15322732 Disease Relevance 0.37 Pain Relevance 0.39
Two types of sigma receptor exist, the sigma-1 receptor and the sigma-2 receptor. sigma-1 receptors have been cloned and their distribution, physiological functions and roles in signal transduction were recently characterised.
Gene_expression (exist) of sigma-2 receptor
13) Confidence 0.50 Published 2004 Journal CNS Drugs Section Abstract Doc Link 15089113 Disease Relevance 0 Pain Relevance 0.30
Indeed, the overexpression of Sig-1R per se in PC12 cells enhanced the NGF-induced neurite sprouting.
Gene_expression (overexpression) of Sig-1R in neurite associated with nerve growth factor
14) Confidence 0.40 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438547 Disease Relevance 0 Pain Relevance 0.73
Western blot and immunohistochemistry were performed to determine changes in Sig-1R expression and to examine the effect of BD1047 on N-methyl-D-aspartate receptor subunit 1 expression and phosphorylation in spinal cord dorsal horn from neuropathic rats.
Gene_expression (expression) of Sig-1R in spinal cord dorsal horn
15) Confidence 0.30 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.16 Pain Relevance 0
Sig-1R expression significantly increased in the ipsilateral spinal cord dorsal horn from days 1 to 3 after CCI.
Gene_expression (expression) of Sig-1R in spinal cord dorsal horn
16) Confidence 0.30 Published 2008 Journal Anesthesiology Section Body Doc Link 18946301 Disease Relevance 0.12 Pain Relevance 0
We introduce three high affinity sigma-1 receptor compounds, N,N-dibutyl-3-(4-fluorophenyl)propylamine (9), N,N-dibutyl-3-(4-nitrophenyl)propylamine (3), and N-propyl-N'-4-aminophenylethyl-3-(4-nitrophenyl)propylamine (20) with K(i) values of 17.7 nM, 0.36 nM, and 6 nM, respectively.
Gene_expression (introduce) of sigma-1 receptor
17) Confidence 0.28 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20493718 Disease Relevance 0.31 Pain Relevance 0.11
In addition, the two sigma receptor subtypes and their two related proteins are also expressed on tumor cells, where they could be of prognostic relevance, and their ligands could potentially be used in the detection and targeting of tumors.
Gene_expression (expressed) of sigma receptor associated with cancer
18) Confidence 0.25 Published 2004 Journal Curr Opin Investig Drugs Section Abstract Doc Link 15573866 Disease Relevance 0.75 Pain Relevance 0.47
The sigma receptor is found in the central nervous system and also in the immune and endocrine systems.
Gene_expression (found) of sigma receptor in endocrine systems associated with central nervous system
19) Confidence 0.22 Published 1990 Journal Ciba Found. Symp. Section Abstract Doc Link 1963396 Disease Relevance 0 Pain Relevance 0.14
The sigma receptor resides likely in the nonsynaptic region of the plasma membrane.
Gene_expression (resides) of sigma receptor in plasma
20) Confidence 0.21 Published 1991 Journal Eur. J. Biochem. Section Abstract Doc Link 1655424 Disease Relevance 0 Pain Relevance 0.25

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