INT128386

Context Info Confidence 0.38 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.25

transmembrane transporter activity (Slc22a8) plasma membrane (Slc22a8)

Anatomy Link Frequency astrocytes 2 Slc22a8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Desipramine 2 85.40 Clonidine 2 82.28 addiction 2 48.52

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RT-PCR demonstrated that astrocytes expressed low levels of OCT1, OCT2 and OCT3 mRNA, but the functional characteristics of choline uptake are very different from the known properties of these OCTs.

Transcription (expressed) of OCT3 in astrocytes

1) Confidence 0.38 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000150 Disease Relevance 0 Pain Relevance 0.12

RT-PCR demonstrated that astrocytes expressed low levels of OCT1, OCT2 and OCT3 mRNA, but the functional characteristics of choline uptake are very different from the known properties of these OCTs.

Transcription (levels) of OCT3 in astrocytes

2) Confidence 0.38 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000150 Disease Relevance 0 Pain Relevance 0.12

General Comments

This test has worked.