INT128401

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 39
Total Number 47
Disease Relevance 10.88
Pain Relevance 15.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
neurons 7
spinal 5
hepatocytes 4
microglia 3
thoracic aorta 3
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 289 100.00 Very High Very High Very High
addiction 10 100.00 Very High Very High Very High
Dopamine 1810 99.98 Very High Very High Very High
Inflammation 117 99.88 Very High Very High Very High
narcan 3 99.84 Very High Very High Very High
dopamine receptor 114 99.80 Very High Very High Very High
Spinal cord 156 99.68 Very High Very High Very High
spinal dorsal horn 57 99.68 Very High Very High Very High
allodynia 20 99.60 Very High Very High Very High
Stimulus evoked pain 33 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 122 99.88 Very High Very High Very High
Neuropathic Pain 38 99.60 Very High Very High Very High
Hypersensitivity 142 99.56 Very High Very High Very High
Pain 259 98.88 Very High Very High Very High
Death 124 98.00 Very High Very High Very High
Diabetes Mellitus 396 97.92 Very High Very High Very High
Stress 20 96.56 Very High Very High Very High
Hyperalgesia 284 95.28 Very High Very High Very High
Nociception 203 95.12 Very High Very High Very High
Bordatella Infection 35 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, TENS application suppressed the CFA-induced ERK2 activation and c-Fos protein expression.
Positive_regulation (induced) of Positive_regulation (activation) of ERK2 associated with transcutaneous nerve stimulation
1) Confidence 0.70 Published 2010 Journal Anat Rec (Hoboken) Section Abstract Doc Link 20583264 Disease Relevance 0.64 Pain Relevance 1.22
This suggests that the PTX effects that have been observed, at least on ERK1/2 activation in response to PGF2?
Positive_regulation (least) of Positive_regulation (activation) of ERK1/2
2) Confidence 0.48 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.08 Pain Relevance 0
Additionally, s.c. injection of either saline or bee venom significantly augmented the activation of ERK1 and ERK2 (Fig. 3A, Tables 1 and 2).
Positive_regulation (augmented) of Positive_regulation (activation) of ERK2
3) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.33 Pain Relevance 0.39
BACKGROUND: We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in hemiparkinsonian rats treated with 3,4-dihydroxyphenyl-L-alanine (L-DOPA).
Spec (examined) Positive_regulation (dependence) of Spec (examined) Positive_regulation (activation) of extracellular signal-regulated kinase 1 and 2 associated with addiction and dopamine receptor
4) Confidence 0.47 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 17662258 Disease Relevance 0.07 Pain Relevance 0.14
BACKGROUND: We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in hemiparkinsonian rats treated with 3,4-dihydroxyphenyl-L-alanine (L-DOPA).
Spec (examined) Positive_regulation (dependence) of Spec (examined) Positive_regulation (activation) of ERK1/2 associated with addiction and dopamine receptor
5) Confidence 0.47 Published 2007 Journal Biol. Psychiatry Section Abstract Doc Link 17662258 Disease Relevance 0.07 Pain Relevance 0.14
Previous findings have demonstrated that Gi dependent activations of ERK1/2 are mediated through ??
Positive_regulation (mediated) of Positive_regulation (activations) of ERK1/2
6) Confidence 0.44 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.06 Pain Relevance 0.06
-induced ERK1/2 activation in hepatocytes.
Positive_regulation (induced) of Positive_regulation (activation) of ERK1/2 in hepatocytes
7) Confidence 0.44 Published 2001 Journal BMC Cell Biol Section Abstract Doc Link PMC37242 Disease Relevance 0.09 Pain Relevance 0
-induced ERK1/2 activation.
Positive_regulation (induced) of Positive_regulation (activation) of ERK1/2
8) Confidence 0.44 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.09 Pain Relevance 0
-induced ERK1/2 activation in hepatocytes.
Positive_regulation (induced) of Positive_regulation (activation) of ERK1/2 in hepatocytes
9) Confidence 0.44 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0 Pain Relevance 0
Thus, weak dopaminergic signaling induced a transient increase in pERK2 while strong dopaminergic signaling induced a sustained activation of ERK2.


Positive_regulation (induced) of Positive_regulation (activation) of ERK2
10) Confidence 0.42 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.20
Cells treated with 2,2'-DCB increased phosphorylated MAPK1, implicating the increase of activation of MAPK1.
Positive_regulation (increase) of Positive_regulation (activation) of MAPK1
11) Confidence 0.41 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.22 Pain Relevance 0.30
With particular relevance to this study, ERK1/2 activation leads to NOS I induction in rat PC12 cells [18] and in rat aortic smooth muscle cells [19].
Positive_regulation (induction) of Positive_regulation (activation) of ERK1/2 in smooth muscle cells
12) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.66 Pain Relevance 0.13
Activation of MEK1/2 or ERK1/2 is not responsible for the augmentation of NOS II or peroxynitrite in RVLM during the pro-death phase
Neg (not) Positive_regulation (responsible) of Positive_regulation (Activation) of ERK1/2 associated with rostral ventrolateral medulla and death
13) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.55 Pain Relevance 0.38
These results suggest that the induction phase and early maintenance phase, but not the late maintenance phase of long-lasting allodynia is mediated by the activation of ERK, rather than by the activation of p38 MAPK, in the spinal cord.
Positive_regulation (activation) of Positive_regulation (activation) of p38 MAPK in spinal cord associated with allodynia and spinal cord
14) Confidence 0.35 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.44 Pain Relevance 0.61
Several lines of evidence suggest that activation of spinal mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK) and p38 MAPK, contributes to the induction and maintenance of chronic pain.
Positive_regulation (contributes) of Positive_regulation (activation) of p38 MAPK in spinal associated with lasting pain
15) Confidence 0.35 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.40 Pain Relevance 0.49
SCH23390 co-applied with eticlopride during NMDA 20 µM stimulation induced significant ERK2 activation compared to control, which was not significantly different from activation of ERK2 in response to NMDA alone (1.57±0.08, n?
Positive_regulation (induced) of Positive_regulation (activation) of ERK2
16) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.46
4, respectively), SCH23390 and eticlopride abolished the dopamine induced ERK2 activation as expected (0.83±0.08, n?
Positive_regulation (induced) of Positive_regulation (activation) of ERK2 associated with dopamine
17) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.55
Co-application induced a significantly stronger activation of ERK2 than that induced by 10 µM dopamine or 10 µM NMDA alone.
Positive_regulation (induced) of Positive_regulation (activation) of ERK2 associated with dopamine
18) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.24
Thus, weak activation of NMDA-receptors (NMDA-R) induced a sustained increase in pERK2 while strong activation of NMDA-Rs induced a robust, but transient activation of ERK2.
Positive_regulation (induced) of Positive_regulation (activation) of ERK2
19) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.11
Surprisingly, we found that dopamine induced ERK2 activation is dependent upon the NMDA receptor but not vice versa (Fig. 4A, B).
Positive_regulation (induced) of Positive_regulation (activation) of ERK2 associated with dopamine and nmda receptor
20) Confidence 0.30 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0 Pain Relevance 0.46

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