INT128404

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.73
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Mapk1, Gja1) cytoplasm (Mapk1, Gja1) cytosol (Mapk1, Gja1)
signal transduction (Mapk1, Gja1) nucleoplasm (Mapk1) mitochondrion (Mapk1)
Anatomy Link Frequency
uterine 8
Mapk1 (Rattus norvegicus)
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 16 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 16 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
MAPK1 Positive_regulation (mediated) of Phosphorylation (phosphorylation) of GJA1 in uterine associated with dismenorea
1) Confidence 0.65 Published 2005 Journal Biol. Reprod. Section Title Doc Link 16000550 Disease Relevance 0.19 Pain Relevance 0.19
The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB).
MAPK1 Positive_regulation (induced) of Phosphorylation (phosphorylation) of connexin43 in uterine associated with dismenorea
2) Confidence 0.47 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.17 Pain Relevance 0.17
The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB).
MAPK1 Positive_regulation (induced) of Phosphorylation (phosphorylation) of GJA1 in uterine associated with dismenorea
3) Confidence 0.47 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.17 Pain Relevance 0.17
2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
MAPK1 Positive_regulation (mediated) of Phosphorylation (phosphorylation) of connexin43 in uterine associated with dismenorea
4) Confidence 0.47 Published 2005 Journal Biol. Reprod. Section Title Doc Link 16000550 Disease Relevance 0.19 Pain Relevance 0.19

General Comments

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