INT128406

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 7.18
Pain Relevance 5.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pax1) DNA binding (Pax1)
Anatomy Link Frequency
deltoid 1
spinal cord 1
notochord 1
sclerotome 1
nociceptor 1
Pax1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 54 99.82 Very High Very High Very High
Hyperalgesia 12 99.82 Very High Very High Very High
Cannabinoid 16 99.60 Very High Very High Very High
withdrawal 10 99.44 Very High Very High Very High
Morphine 8 99.26 Very High Very High Very High
Spinal cord 8 99.20 Very High Very High Very High
Analgesic 5 98.86 Very High Very High Very High
agonist 7 98.84 Very High Very High Very High
Inflammatory response 7 98.66 Very High Very High Very High
Cannabinoid receptor 4 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 1 100.00 Very High Very High Very High
Targeted Disruption 4 99.88 Very High Very High Very High
Pain 25 99.82 Very High Very High Very High
Hyperalgesia 12 99.82 Very High Very High Very High
Thalassemia 36 99.76 Very High Very High Very High
INFLAMMATION 86 98.48 Very High Very High Very High
Sickle Cell Anemia 94 98.20 Very High Very High Very High
Infection 12 95.32 Very High Very High Very High
Immunization 23 95.12 Very High Very High Very High
Hepatitis 24 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pax1 expression in the sclerotome is mediated by Shh and noggin signaling that originates from the notochord (Fan and Tessier-Lavigne, 1994; Furumoto et al., 1999; McMahon et al., 1998).
Gene_expression (expression) of Pax1 in notochord
1) Confidence 0.60 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.07 Pain Relevance 0.03
Prior to formation of the disc and vertebral body anlagens, almost all sclerotome cells express Pax1.
Gene_expression (express) of Pax1 in sclerotome
2) Confidence 0.60 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.06 Pain Relevance 0
We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS).
Gene_expression (expressing) of HbS associated with targeted disruption, pain, cannabinoid, analgesic and morphine
3) Confidence 0.43 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.64 Pain Relevance 0.87
Importantly, cannabinoids attenuate pain in mice expressing HbS.
Gene_expression (expressing) of HbS associated with pain and cannabinoid
4) Confidence 0.37 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.74 Pain Relevance 1.17
These neurochemical changes in the periphery and spinal cord may contribute to hyperalgesia in mice expressing HbS.
Gene_expression (expressing) of HbS in spinal cord associated with hyperalgesia and spinal cord
5) Confidence 0.37 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.91 Pain Relevance 1.50
We show that mice expressing HbS exhibit characteristics of pain observed in sickle cell disease patients, and neurochemical changes suggestive of nociceptor and glial activation.
Gene_expression (expressing) of HbS in nociceptor associated with sickle cell anemia, pain, nociceptor and glial activation
6) Confidence 0.37 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.74 Pain Relevance 1.40
Our strategy produced differentiated cell cultures that expressed intermediate markers of endoderm and parathyroid development (CXCR4, EYA1, Six1, and Pax1), as well as markers of committed parathyroid precursors or developed parathyroid glands (glial cell missing-2 [Gcm2], CCL21, calcium sensing receptor [CaSR], and parathyroid hormone [PTH]).
Gene_expression (expressed) of Pax1 in endoderm
7) Confidence 0.34 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 19025488 Disease Relevance 0.06 Pain Relevance 0.13
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of pax1 associated with inflammatory response
8) Confidence 0.33 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.87 Pain Relevance 0.35
After establishing immunologic activity of the vaccines in mice, groups of three to six HLA-A2-positive patients were enrolled into one of three cohorts in which they received intramuscular injections of the MART-1 plasmid into the right deltoid and the HBsAg plasmid into the left deltoid at doses of 0.1, 0.3, or 1.0 mg on days 1, 43, 85, and 127.
Gene_expression (injections) of HBsAg in deltoid
9) Confidence 0.16 Published 2005 Journal J. Immunother. Section Abstract Doc Link 16000957 Disease Relevance 0.90 Pain Relevance 0.09
Our strategy produced differentiated cell cultures that expressed intermediate markers of endoderm and parathyroid development (CXCR4, EYA1, Six1, and Pax1), as well as markers of committed parathyroid precursors or developed parathyroid glands (glial cell missing-2 [Gcm2], CCL21, calcium sensing receptor [CaSR], and parathyroid hormone [PTH]).
Gene_expression (expressed) of Pax1 in parathyroid
10) Confidence 0.11 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 19025488 Disease Relevance 0.06 Pain Relevance 0.13
These animals also had detectable serum levels of IgA anti-HBsAg (data not shown).
Gene_expression (levels) of HBsAg
11) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2496893 Disease Relevance 0.25 Pain Relevance 0.12
Another study, comparing hepcidin in 16 patients with sickle syndromes (HbSS, HbS?
Gene_expression (syndromes) of HbS associated with syndrome
12) Confidence 0.01 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 1.88 Pain Relevance 0.12

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