INT12841

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.34
Pain Relevance 3.70

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signal transduction (Gnao1) aging (Gnao1) intracellular (Gnao1)
GTPase activity (Gnao1) protein complex (Gnao1) signal transducer activity (Gnao1)
Anatomy Link Frequency
locus coeruleus 1
Gnao1 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 2 99.68 Very High Very High Very High
Analgesic 3 99.62 Very High Very High Very High
Opioid 9 99.32 Very High Very High Very High
antinociception 6 99.12 Very High Very High Very High
Clonidine 3 98.96 Very High Very High Very High
Morphine 4 97.80 Very High Very High Very High
analgesia 1 96.60 Very High Very High Very High
opioid receptor 8 92.20 High High
agonist 10 91.08 High High
withdrawal 7 89.44 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 96.16 Very High Very High Very High
Vibrio Infection 9 93.16 High High
Bordatella Infection 1 92.16 High High
Glioma 1 87.56 High High
Neuroblastoma 1 87.20 High High
Sprains And Strains 4 84.88 Quite High
Drug Dependence 3 75.00 Quite High
Substance Withdrawal Syndrome 1 59.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Gnao1 in the locus coeruleus was found to be upregulated in morphine-dependent B6 but not A/J mice.
Gene_expression (expression) of Gnao1 in locus coeruleus associated with locus ceruleus and morphine
1) Confidence 0.60 Published 2009 Journal Neuroscience Section Abstract Doc Link 19460419 Disease Relevance 0.49 Pain Relevance 0.92
Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.
Gene_expression (restore) of Go alpha associated with targeted disruption, antinociception, analgesic, opioid and clonidine
2) Confidence 0.22 Published 1999 Journal Neuropharmacology Section Title Doc Link 10608281 Disease Relevance 0.28 Pain Relevance 0.98
After impairing the synthesis of Go1 alpha subunits, DPDPE exhibited an antagonistic activity on the antinociception produced by [D-Ala2]deltorphin II.
Gene_expression (synthesis) of Go1 alpha associated with antinociception
3) Confidence 0.06 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580632 Disease Relevance 0 Pain Relevance 1.09
The extent of reduction differed for different types of subunits: the levels of Go alpha and G beta 1 were reduced by 40-50%, whereas those of G alpha common immunoreactivity and Gi2 alpha were only reduced by 10-20% following treatment with 10 micrograms/ml cholera toxin.
Gene_expression (levels) of Go alpha associated with vibrio infection
4) Confidence 0.03 Published 1990 Journal Eur. J. Biochem. Section Abstract Doc Link 2158884 Disease Relevance 0.57 Pain Relevance 0
Moreover, P1 LMs contained more Go alpha protein than P1 HMs or adult LMs, as demonstrated by immunoblotting with antisera against Go alpha after one- or two-dimensional gel electrophoresis.
Gene_expression (contained) of Go alpha
5) Confidence 0.03 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1655974 Disease Relevance 0 Pain Relevance 0.33
Both antisera OC2 and ON1 were able to immunoprecipitate Go alpha quantitatively.
Gene_expression (able) of Go alpha
6) Confidence 0.01 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8393523 Disease Relevance 0 Pain Relevance 0.37

General Comments

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