INT128412

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.58
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cand1) nucleus (Cand1)
Anatomy Link Frequency
coronary artery 1
plasma 1
spinal 1
heart 1
Cand1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 2 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
Dorsal horn neuron 1 98.08 Very High Very High Very High
Neuropathic pain 4 96.48 Very High Very High Very High
spinal dorsal horn 3 93.96 High High
Peripheral nerve injury 1 90.84 High High
Thermal hyperalgesia 2 79.04 Quite High
Sciatic nerve 1 75.16 Quite High
Dorsal horn 2 65.36 Quite High
adenocard 2 51.76 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 72 100.00 Very High Very High Very High
Coronary Artery Disease 31 98.84 Very High Very High Very High
Neuropathic Pain 5 96.48 Very High Very High Very High
Hyperlipidemia 8 92.08 High High
Nervous System Injury 1 90.40 High High
Injury 2 87.96 High High
Hyperplasia 1 85.80 High High
Cardiovascular Disease 10 83.40 Quite High
Hyperalgesia 3 79.04 Quite High
Pressure And Volume Under Development 15 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of Homer1b/c and Shank1a in the post-synaptic density of spinal dorsal horn neurons are associated with neuropathic pain in rats.
Positive_regulation (Increased) of c and in spinal associated with neuralgia, neuropathic pain and dorsal horn neuron
1) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 16002212 Disease Relevance 0.55 Pain Relevance 1.05
After 12 weeks of therapy with cilostazol, a 10% increase in HDL-C and a 15% decrease in plasma triglycerides have been noted (Elam et al 1998; Lee et al 2001).
Positive_regulation (increase) of C and in plasma associated with disorder of lipid metabolism
2) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663440 Disease Relevance 0.76 Pain Relevance 0.03
Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.
Positive_regulation (elevations) of C and in heart
3) Confidence 0.45 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
In this study, pitavastatin administration produced a decrease of the serum total cholesterol by 26.9% and of the serum LDL-C levels by 39.8%, with increase of the serum HDL-C and HDL2-C levels by 6.0% and 9.0%, respectively.
Positive_regulation (increase) of C and associated with disorder of lipid metabolism
4) Confidence 0.45 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.97 Pain Relevance 0
Decreased plasma levels of CETP are associated with increased levels of HDL-C and, in turn, decreased risk of coronary artery disease (CAD).8–10 These effects have been correlated also with specific mutations in the CETP gene.8,11,12
Positive_regulation (increased) of C and in coronary artery associated with coronary artery disease and disorder of lipid metabolism
5) Confidence 0.45 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 1.30 Pain Relevance 0

General Comments

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