INT12842

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2b1)
Cyp2b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 12 99.98 Very High Very High Very High
Opioid 2 93.28 High High
Enkephalin 2 91.48 High High
Paracetamol 4 78.84 Quite High
Analgesic 2 76.64 Quite High
mu opioid receptor 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two isotopically substituted analogs of APAP, [2,3',5'-13C3]-4'-hydroxyacetanilide and 4'-hydroxyacet-[15N]-anilide, were synthesized, and their binding to purified CYP1A1 and CYP2B1 was examined by NMR spectroscopy.
CYP2B1 Binding (binding) of
1) Confidence 0.48 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.13
Investigations of the binding of APAP to CYP1A1 and CYP2B1 were carried out to assess the possibility that different preferred orientations of APAP in the active sites of these isoforms may, in part, by responsible for their different product selectivities.
CYP2B1 Binding (binding) of
2) Confidence 0.37 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.23
Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2.
P450 2B1 Binding (binding) of associated with lidocaine
3) Confidence 0.20 Published 1998 Journal Biochemistry Section Title Doc Link 9425052 Disease Relevance 0 Pain Relevance 0.86
P1 LM mu binding possessed greater sensitivity to 5'-guanylylimidodiphosphate than their adult counterpart.
P1 LM Binding (binding) of
4) Confidence 0.02 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1655974 Disease Relevance 0 Pain Relevance 0.35

General Comments

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