INT128422

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.24
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
monocytes 3
intestinal cells 2
neuronal 2
epithelial cells 2
macrophages 1
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 213 90.16 High High
chemokine 29 89.96 High High
cytokine 148 89.28 High High
ischemia 2 73.80 Quite High
cINOD 4 61.44 Quite High
Pain 7 45.44 Quite Low
imagery 2 42.88 Quite Low
COX2 2 25.00 Low Low
antagonist 37 5.00 Very Low Very Low Very Low
Inflammatory response 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 10 100.00 Very High Very High Very High
Asthma 315 99.84 Very High Very High Very High
Injury 17 98.60 Very High Very High Very High
Infection 15 97.42 Very High Very High Very High
Apoptosis 96 95.92 Very High Very High Very High
Cancer 164 94.52 High High
Carcinoma 2 93.76 High High
INFLAMMATION 247 90.16 High High
Death 27 78.88 Quite High
Lentivirus Infections 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present studies indicate that FIV infection of DRGs directly contributes to axonal and neuronal injury through a mechanism involving macrophage immune activation, which is mediated by STAT-1 and iNOS activation.
Positive_regulation (mediated) of Positive_regulation (activation) of STAT-1 in neuronal associated with injury and infection
1) Confidence 0.35 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 0.75 Pain Relevance 0
To determine whether there is a general differential requirement for STAT1 in gene activation and gene repression in response to IFNgamma in intestinal cells, we performed genome-wide analysis of IFNgamma target genes in an IEC line in which STAT1 expression was silenced by small interfering RNA.
Spec (whether) Positive_regulation (requirement) of Spec (whether) Positive_regulation (response) of STAT1 in intestinal cells associated with repression
2) Confidence 0.32 Published 2007 Journal Oncogene Section Abstract Doc Link 17016440 Disease Relevance 0.49 Pain Relevance 0.06
specific antibody, or silencing of STAT1, a transcription factor that we showed is required for the release of IL-1?
Positive_regulation (required) of Positive_regulation (silencing) of STAT1
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.42 Pain Relevance 0
STAT1 expression and activation is elevated in asthmatic bronchial epithelial cells in some, but not all [117], studies [118].
Positive_regulation (elevated) of Positive_regulation (activation) of STAT1 in epithelial cells associated with asthma
4) Confidence 0.20 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.13
-induced STAT1 activation in T84 epithelial and THP-1 monocytes/macrophages [118].
Positive_regulation (induced) of Positive_regulation (activation) of STAT1 in monocytes
5) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.55 Pain Relevance 0.24
-induced STAT1 activation in T84 epithelial and THP-1 monocytes/macrophages [118].
Positive_regulation (induced) of in macrophages Positive_regulation (activation) of STAT1 in monocytes
6) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.55 Pain Relevance 0.24

General Comments

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