INT128424

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.28
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT1) nucleoplasm (STAT1) nucleolus (STAT1)
nucleus (STAT1) enzyme binding (STAT1) cytoplasm (STAT1)
Anatomy Link Frequency
SH2 1
STAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 107 98.60 Very High Very High Very High
qutenza 3 93.52 High High
Pain 4 69.72 Quite High
Inflammation 78 67.72 Quite High
tolerance 7 65.76 Quite High
depression 2 56.80 Quite High
Arthritis 41 53.88 Quite High
Inflammatory response 14 12.80 Low Low
Inflammatory mediators 2 7.76 Low Low
cytokine 46 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 107 98.60 Very High Very High Very High
Hepatitis C Virus Infection 32 96.88 Very High Very High Very High
Infection 10 95.80 Very High Very High Very High
Multiple Myeloma 9 95.16 Very High Very High Very High
Targeted Disruption 2 90.84 High High
Injury 11 90.40 High High
Alagille Syndrome 1 87.80 High High
Neuropathy 4 81.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 77.16 Quite High
Lentivirus Infections 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased STAT-1 and iNOS mRNA levels were also observed in DRGs from FIV-infected animals relative to mock-infected controls.
Transcription (levels) of STAT-1
1) Confidence 0.37 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.39 Pain Relevance 0.10
induced transcription factor STAT1 and its binding to DNA response elements, thereby increasing the induction of ISGs and enhancing the inhibitory effect of IFN?
Transcription (transcription) of STAT1
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975710 Disease Relevance 0.37 Pain Relevance 0
The important participants in the Interleukin-6 signaling pathway include the Janus kinases (JAKs) Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3, the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] and transcription factor NF-?
Transcription (transcription) of STAT1 in SH2
3) Confidence 0.20 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.34 Pain Relevance 0.06
Because the transcription factor signal transducer and activator of transcription 3 (STAT3) has been closely linked with tumorigenesis, we investigated the effect of this vanilloid on the STAT3 pathway in human multiple myeloma cells.
Transcription (transcription) of transcription factor signal transducer associated with multiple myeloma
4) Confidence 0.04 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17505005 Disease Relevance 0.10 Pain Relevance 0.17
Signal transducer and activator of transcription 4
Transcription (transcription) of Signal transducer and activator
5) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 1.09 Pain Relevance 0.58

General Comments

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