INT12844

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 10.57
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
uterus 2
embryos 1
Th17 cells 1
arms 1
uterine 1
TP63 (Homo sapiens)
TP63 - P1308L (1)
Pain Link Frequency Relevance Heat
psoriasis 232 98.44 Very High Very High Very High
Opioid 2 97.00 Very High Very High Very High
cytokine 52 95.98 Very High Very High Very High
Enkephalin 2 95.20 Very High Very High Very High
Arthritis 68 92.20 High High
interstitial cystitis 8 88.72 High High
Neurotransmitter 1 88.24 High High
peptic ulcer disease 1 87.56 High High
Inflammation 86 80.64 Quite High
Etanercept 36 79.64 Quite High
Disease Link Frequency Relevance Heat
Leiomyosarcoma 93 100.00 Very High Very High Very High
Canker Sores 8 100.00 Very High Very High Very High
Nasopharynx Cancer 145 99.52 Very High Very High Very High
Mouth Ulcer 1 99.08 Very High Very High Very High
Psoriasis 274 98.44 Very High Very High Very High
Cancer 120 98.16 Very High Very High Very High
Disease 116 98.00 Very High Very High Very High
Toxicity 15 97.26 Very High Very High Very High
Autoimmune Disease 11 97.16 Very High Very High Very High
Congenital Anomalies 5 96.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the abnormalities found in bladder epithelial cells from IC/PBS patients have been shown to be induced in normal cells by an antiproliferative factor from IC/PBS bladder epithelial cells that binds to a functional cell membrane receptor (CKAP4/p63).
p63 Binding (binds) of in bladder associated with congenital anomalies
1) Confidence 0.47 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18602988 Disease Relevance 0.46 Pain Relevance 0.50
This retrospective analysis aimed to describe the activity and outcome of chemotherapy in patients with advanced/metastatic LMS and to assess whether there are differences between LMS originating in the uterus versus LMS originating elsewhere.

2.

LMS Binding (originating) of in uterus
2) Confidence 0.28 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.52 Pain Relevance 0
This retrospective analysis aimed to describe the activity and outcome of chemotherapy in patients with advanced/metastatic LMS and to assess whether there are differences between LMS originating in the uterus versus LMS originating elsewhere.

2.

LMS Binding (originating) of in uterus
3) Confidence 0.28 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.52 Pain Relevance 0
The results of immunoprecipitation suggested a direct interaction between EBNA-5 and p63 protein in NPC, and this binding would increase the stability of p63.
p63 Spec (suggested) Binding (interaction) of associated with nasopharynx cancer
4) Confidence 0.18 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.26 Pain Relevance 0
Although NaCl inhibited mu binding in LMs to a greater extent than in HMs, age-dependent differences were not observed.
LMs Binding (binding) of
5) Confidence 0.11 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1655974 Disease Relevance 0 Pain Relevance 0.36
Recent advances in our understanding of the biology of uterine LMS have concentrated on the impaired IFN-?
LMS Binding (biology) of in uterine associated with leiomyosarcoma
6) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.92 Pain Relevance 0
It does so by binding to their shared p40 subunit, therefore blocking the interaction with their cognate receptors.41 This agent thus targets Th1 and Th17 arms of immunity, both of which we now know are key parts in the immunopathogenesis of psoriasis.
p40 Binding (binding) of in arms associated with psoriasis
7) Confidence 0.10 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.64 Pain Relevance 0.29
The new psoriasis model is explained by the interaction between epidermal keratinocytes and various immunocytes, including the four different CD4+ subsets: Th1, Th2, Th17, and T-regs.18 Recently discovered Th17 cells form part of a pathway mainly regulated by IL-23 (among several cytokines), and have been associated with regulation of autoimmunity.3 Although initial experiments were targeted towards IL-12’s p40 subunit, serendipitous findings suggested that IL-23 (which shares a common p40 subunit with IL-12) was more important in the psoriasis immunopathogenesis, shifting the paradigm to a Th1/Th17 hypothesis.19,20
p40 Binding (subunit) of in Th17 cells associated with psoriasis, autoimmune disease and cytokine
8) Confidence 0.09 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.89 Pain Relevance 0.48
The N-terminal and DNA-binding domains are the immunodominant regions, and antibody cross-reactivity with p53, p63, and p73 isoforms is limited.
p63 Binding (cross-reactivity) of
9) Confidence 0.06 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17720849 Disease Relevance 0.58 Pain Relevance 0.06
Immunofluorescent confocal microscopy showed co-localization of anti-CKAP4/p63 and rhodamine-labeled synthetic APF binding in both cell membrane and perinuclear areas.
p63 Binding (binding) of
10) Confidence 0.06 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 17030514 Disease Relevance 0.32 Pain Relevance 0.15
Use of the FET in context of effluent assessments was considered and it is not known if fish embryos are sufficiently sensitive for consideration as a surrogate to the sub-chronic 7-day larval fish growth and survival test used in the United States, for example.
sub-chronic Binding (surrogate) of in embryos associated with toxicity
11) Confidence 0.05 Published 2010 Journal Aquat. Toxicol. Section Abstract Doc Link 20061034 Disease Relevance 0.54 Pain Relevance 0.06
This study demonstrates that cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor, binds with high affinity to APF.
p63 Binding (binds) of
12) Confidence 0.05 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 17030514 Disease Relevance 0.32 Pain Relevance 0.16
This study demonstrates that cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor, binds with high affinity to APF.
p63 Binding (binds) of
13) Confidence 0.05 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 17030514 Disease Relevance 0.32 Pain Relevance 0.16
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
p40 Binding (alteration) of associated with psoriasis
14) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.51
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
p40 Binding (alteration) of associated with psoriasis
15) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.51
The intensities of WT, P1308L, V1298F channels were normalized with the intensities of ?
P1308L (P1308L) Binding (normalized) of
16) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0 Pain Relevance 0.04
Given the histological similarities between gastric and oral ulceration, it seemed prudent to investigate a possible association between H. pylori and recurrent aphthous stomatitis (RAS).
stomatitis Binding (association) of associated with mouth ulcer and canker sores
17) Confidence 0.00 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 11048967 Disease Relevance 1.23 Pain Relevance 0.09

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