INT128446

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.01
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (DYM) cytoplasm (DYM)
Anatomy Link Frequency
aorta 1
artery smooth muscle 1
DYM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 99.54 Very High Very High Very High
Serotonin 3 85.80 High High
antagonist 2 82.32 Quite High
fluoxetine 1 80.48 Quite High
monoamine 2 75.04 Quite High
Angina 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 22 99.72 Very High Very High Very High
INFLAMMATION 17 99.54 Very High Very High Very High
Breast Cancer 12 99.36 Very High Very High Very High
Vascular System Injuries 8 99.30 Very High Very High Very High
Coronary Heart Disease 18 98.88 Very High Very High Very High
Congenital Anomalies 5 98.24 Very High Very High Very High
Atherosclerosis 17 98.08 Very High Very High Very High
Myocardial Infarction 62 97.96 Very High Very High Very High
Cancer 38 97.32 Very High Very High Very High
Aging 6 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vascular SMC serum response might reflect vascular injury; perhaps the hypoxia response and SMC serum response are both elevated in a subset of breast tumors with vascular abnormalities and poor tumor oxygenation.
Positive_regulation (elevated) of SMC associated with cancer, congenital anomalies, hypoxia, breast cancer and vascular system injuries
1) Confidence 0.14 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 1.67 Pain Relevance 0
The histopathology of ACD is characterized by inflammatory cell infiltrates with SMC accumulation and hence is more akin to ISR than the complex atherosclerotic lesions.
Positive_regulation (accumulation) of SMC associated with inflammation, atherosclerosis and coronary heart disease
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267220 Disease Relevance 1.22 Pain Relevance 0.08
To begin to address the functional role of FAM5C in MI, we observed that FAM5C is expressed in the human aorta and that its transcript levels decrease with increasing passage of AoSMC, suggesting that the level of gene expression may play a role in proliferation and senescence of this cell type.
Positive_regulation (increasing) of AoSMC in aorta associated with aging and myocardial infarction
3) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.79 Pain Relevance 0
Because 5-HT induces release of S100beta, we investigated the codependence of 5-HT receptors and SERT in regulating S100A4/Mts1 in human pulmonary artery smooth muscle cells (hPA-SMC). 5-HT elevated S100A4/Mts1 mRNA levels and increased S100A4/Mts1 protein in hPA-SMC lysates and culture media.
Positive_regulation (elevated) of hPA-SMC in artery smooth muscle
4) Confidence 0.00 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16002749 Disease Relevance 0.34 Pain Relevance 0.31

General Comments

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