INT128447

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
Anatomy Link Frequency
astrocytes 2
artery smooth muscle 2
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 45 99.88 Very High Very High Very High
bDMF 5 99.48 Very High Very High Very High
Serotonin 3 92.88 High High
antagonist 1 64.16 Quite High
fluoxetine 4 62.32 Quite High
monoamine 2 56.88 Quite High
depression 14 56.32 Quite High
sSRI 4 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.40 Very High Very High Very High
Hypertension 2 95.00 High High
Depression 56 88.72 High High
Neurodegenerative Disease 3 83.64 Quite High
Schizophrenia 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Cognitive Disorders Amnestic Dementia Delirium 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because 5-HT induces release of S100beta, we investigated the codependence of 5-HT receptors and SERT in regulating S100A4/Mts1 in human pulmonary artery smooth muscle cells (hPA-SMC). 5-HT elevated S100A4/Mts1 mRNA levels and increased S100A4/Mts1 protein in hPA-SMC lysates and culture media.
Positive_regulation (induces) of Localization (release) of S100beta in artery smooth muscle
1) Confidence 0.67 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16002749 Disease Relevance 0.36 Pain Relevance 0.25
Antidepressants stimulate the secretion of neurotrophic factors, such as brain derived neurotrophic factor (BDNF).38 Antidepressants also enhance the secretion of S100B by astrocytes via serotonergic systems.15,39-41 Interestingly, in this study, the increase in serum S100B levels in response to treatment with antidepressants was more prominent in nonresponders than in responders.
Positive_regulation (enhance) of Localization (secretion) of S100B in astrocytes associated with antidepressant and bdmf
2) Confidence 0.36 Published 2008 Journal Psychiatry Investigation Section Body Doc Link PMC2796025 Disease Relevance 0.54 Pain Relevance 0.54

General Comments

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