INT128451

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.28
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (RNLS) extracellular region (RNLS)
RNLS (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 5 100.00 Very High Very High Very High
Catecholamine 45 96.16 Very High Very High Very High
fluoxetine 1 94.84 High High
antagonist 1 94.38 High High
ischemia 54 89.12 High High
imagery 6 80.64 Quite High
Serotonin 3 75.00 Quite High
tolerance 3 16.76 Low Low
Angina 3 5.00 Very Low Very Low Very Low
Parenteral administration 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 36 92.24 High High
Cv Unclassified Under Development 48 89.12 High High
Coronary Heart Disease 48 88.04 High High
Left Ventricular Hypertrophy 18 76.20 Quite High
Increased Venous Pressure Under Development 3 75.00 Quite High
Obesity 12 71.24 Quite High
Hypertension 17 64.36 Quite High
Stress 15 43.84 Quite Low
Cardiovascular Disease 3 43.20 Quite Low
Nicotine Addiction 6 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies should be aimed at determining whether there is a potential therapeutic role for renalase replacement in persons at high risk of cardiovascular morbidity and mortality.



Spec (whether) Positive_regulation (role) of renalase
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.35 Pain Relevance 0.13
Renalase is a FAD dependent oxidoreductase, which uses NADH as a cofactor to reduce its FAD moiety.
Positive_regulation (dependent) of Renalase
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.43 Pain Relevance 0.12
Data from the International HapMap Consortium has identified a single common non-synonymous single-nucleotide polymorphism in the human renalase gene that results in an aspartic acid to glutamic acid substitution at codon 37 (Glu37Asp) in the flavin-adenine dinucleotide-binding site.
Positive_regulation (results) of renalase gene
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958117 Disease Relevance 0.24 Pain Relevance 0.09
Treatment with SB224289 (selective antagonist of 5-HT1B), fluoxetine (SERT inhibitor), SERT RNA-interference, and iproniazid (monoamine oxidase-A inhibitor), blocked 5-HT-induced S100A4/Mts1. 5-HT signaling mediated phosphorylation (p) of extracellular signal-regulated kinase 1/2 (pERK1/2), but pERK1/2 nuclear translocation depended on SERT, monoamine oxidase activity, and reactive oxygen species.
Positive_regulation (depended) of monoamine oxidase associated with antagonist, monoamine and fluoxetine
4) Confidence 0.06 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16002749 Disease Relevance 0.27 Pain Relevance 0.34

General Comments

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