INT128467

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 5.65
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Fxyd3)
Fxyd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 18 93.08 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 36 99.84 Very High Very High Very High
Adenocarcinoma 30 99.12 Very High Very High Very High
Malignant Neoplastic Disease 6 97.00 Very High Very High Very High
Pancreatitis 18 93.08 High High
Cancer 12 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FXYD3 antisense expressing T3M4 pancreatic cancer cells were generated and compared to control cells using anchorage-dependent and independent growth assays, and xenotransplantation into nude mice.
Gene_expression (expressing) of FXYD3 associated with pancreatic cancer
1) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16003754 Disease Relevance 1.11 Pain Relevance 0.25
FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth.
Gene_expression (overexpressed) of FXYD3 associated with adenocarcinoma and pancreatic cancer
2) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Title Doc Link 16003754 Disease Relevance 1.05 Pain Relevance 0.23
Anchorage-independent growth and sensitivity to 5-fluorouracil, gemcitabine and cisplatin as well as to MgCl(2) were not dependent on the level of FXYD3 expression.
Gene_expression (expression) of FXYD3
3) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16003754 Disease Relevance 1.03 Pain Relevance 0.18
The expression and localization of FXYD domain containing ion transport regulator 3 (FXYD3), a transmembrane protein that acts as a chloride channel or chloride channel regulator, was analyzed in pancreatic tissues derived from donors and patients suffering from chronic pancreatitis (CP) or pancreatic ductal adenocarcinoma (PDAC) as well as in pancreatic cancer cells using QRT-PCR, laser-capture microdissection and microarray analysis, in situ hybridization and immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of FXYD3 associated with adenocarcinoma, pancreatic cancer and chronic pancreatitis
4) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16003754 Disease Relevance 0.67 Pain Relevance 0.19
In conclusion, overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy.
Gene_expression (overexpression) of FXYD3 associated with malignant neoplastic disease and pancreatic cancer
5) Confidence 0.78 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16003754 Disease Relevance 1.11 Pain Relevance 0.08
The expression and localization of FXYD domain containing ion transport regulator 3 (FXYD3), a transmembrane protein that acts as a chloride channel or chloride channel regulator, was analyzed in pancreatic tissues derived from donors and patients suffering from chronic pancreatitis (CP) or pancreatic ductal adenocarcinoma (PDAC) as well as in pancreatic cancer cells using QRT-PCR, laser-capture microdissection and microarray analysis, in situ hybridization and immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of FXYD3 associated with adenocarcinoma, pancreatic cancer and chronic pancreatitis
6) Confidence 0.68 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16003754 Disease Relevance 0.67 Pain Relevance 0.19

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