INT128472

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.92
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34)
extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)
Anatomy Link Frequency
endothelial cells 1
fibroblast 1
CD34 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 89.64 High High
agonist 6 86.44 High High
Inflammation 9 81.28 Quite High
abdominal pain 1 80.36 Quite High
analgesia 1 77.16 Quite High
nud 1 75.84 Quite High
ischemia 4 56.12 Quite High
antagonist 1 19.76 Low Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 86 100.00 Very High Very High Very High
Malignant Neoplastic Disease 5 98.60 Very High Very High Very High
Lung Cancer 2 98.20 Very High Very High Very High
Necrosis 3 96.96 Very High Very High Very High
Hyperplasia 3 96.44 Very High Very High Very High
Coronary Artery Disease 27 96.32 Very High Very High Very High
Endometrial Cancer 3 94.80 High High
Reprotox - General 1 28 90.48 High High
Pain 1 89.64 High High
Uterine Cancer 2 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lesion was strongly positive for epithelial membrane antigen and also positive for CD34.
Negative_regulation (positive) of CD34
1) Confidence 0.42 Published 2010 Journal Ann Diagn Pathol Section Abstract Doc Link 20227017 Disease Relevance 0.75 Pain Relevance 0.16
The tumor cells were Vimentin and CD 10 diffuse positive, focal Actin positive, Desmin, KL 1, CD 34 and S 100 protein-negative. 85% of the tumor cells were PCNA positive and 25 % were Ki 67 positive.
Negative_regulation (positive) of CD 34 associated with cancer
2) Confidence 0.42 Published 2004 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 16004219 Disease Relevance 0.73 Pain Relevance 0.09
Implantation of CD34 antibody coated stents
Negative_regulation (Implantation) of CD34
3) Confidence 0.40 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.46 Pain Relevance 0.26
Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma.
Negative_regulation (result) of CD34 associated with malignant neoplastic disease and lung cancer
4) Confidence 0.31 Published 2009 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 19346724 Disease Relevance 0.58 Pain Relevance 0.08
The MVD was assessed using CD31 and CD34 counts separately.


Negative_regulation (using) of CD34
5) Confidence 0.22 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1435760 Disease Relevance 0.08 Pain Relevance 0
Stro-1 immunoselection of cells derived from human bone marrow revealed all fibroblast-colony-forming units to be positive for Stro-1 but to lack the CD34 antigen, indicating CD34 to be a nonspecific marker of human MSCs [50].
Negative_regulation (lack) of CD34 in fibroblast
6) Confidence 0.21 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.28 Pain Relevance 0
Vascular channels were not lined by endothelial cells as evidenced by the lack of CD34 (brown) staining around the pool of RBCs (Figure 6d).
Negative_regulation (lack) of CD34 in endothelial cells
7) Confidence 0.20 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 1.03 Pain Relevance 0

General Comments

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