INT128478

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 8.10
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
microglia 8
leukocytes 3
granulocytes 2
macrophages 2
fat 1
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 312 98.02 Very High Very High Very High
cytokine 280 97.56 Very High Very High Very High
Central nervous system 91 96.40 Very High Very High Very High
Inflammatory response 25 91.60 High High
cINOD 53 79.64 Quite High
Hippocampus 22 76.56 Quite High
abdominal pain 5 52.76 Quite High
nud 4 52.12 Quite High
Pain 4 49.16 Quite Low
anesthesia 10 39.52 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 66 99.84 Very High Very High Very High
Injury 136 99.62 Very High Very High Very High
Stroke 145 99.32 Very High Very High Very High
Disease 350 99.24 Very High Very High Very High
INFLAMMATION 350 98.02 Very High Very High Very High
Multiple Sclerosis 154 97.20 Very High Very High Very High
Cancer 114 97.12 Very High Very High Very High
Targeted Disruption 49 95.12 Very High Very High Very High
Hypersensitivity 43 89.60 High High
Myocardial Infarction 48 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As CD45 is upregulated on activated microglial cells, which reside in high numbers in CVOs [21], the increased number of CD45+ cells detected within the CVOs during EAE is most probably due to both the recruitment of circulating CD45+ immune cells from the periphery into these areas and additionally to the upregulation of CD45 on microglial cells residing within the CVOs.
Positive_regulation (upregulation) of CD45 in microglial cells associated with multiple sclerosis
1) Confidence 0.44 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.44 Pain Relevance 0.14
As CD45 is upregulated on activated microglial cells, which reside in high numbers in CVOs [21], the increased number of CD45+ cells detected within the CVOs during EAE is most probably due to both the recruitment of circulating CD45+ immune cells from the periphery into these areas and additionally to the upregulation of CD45 on microglial cells residing within the CVOs.
Positive_regulation (upregulated) of CD45 in microglial cells associated with multiple sclerosis
2) Confidence 0.44 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.62 Pain Relevance 0.16
We wondered whether determination of upregulation of CD45, which is widely used to detect both resting and activated microglia in flow cytometry [24,27-29,31] and histology [32,33], might lead to increased detection.
Positive_regulation (upregulation) of CD45 in microglia
3) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0.07
peptide, was significantly inhibited by cross-linking CD45RB (Fig. 4A, top and bottom panels).
Positive_regulation (linking) of CD45RB
4) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.09 Pain Relevance 0
Conversely, stimulation of microglial CD45 by CD45 antibody markedly inhibited these effects via inhibition of p44/42 MAPK, suggesting CD45 is a negative regulator of microglial activation.
Positive_regulation (stimulation) of CD45
5) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.37 Pain Relevance 0.06
We suggest antagonism of p38 by CD45RB stimulation leads to significant reductions in phospho-p38 as shown in figure 2D.
Positive_regulation (stimulation) of CD45RB
6) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.56 Pain Relevance 0.17
To further investigate whether CD45RB signaling-associated cytokines could be involved in modulating microglial phagocytosis by inhibiting p38 MAPK activity, we examined the effect of cross-linking of CD45RB on the production of TNF-?
Positive_regulation (linking) of CD45RB associated with cytokine
7) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.18 Pain Relevance 0.09
To explore the possibility of immunomodulating CD40 activity, we showed that CD45, a protein tyrosine phosphatase (PTP), activation inhibits CD40L-induced microglial activation via down-regulation of the p44/42 mitogen activated protein kinase (MAPK) pathway [14].
Positive_regulation (activation) of CD45
8) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.60 Pain Relevance 0.32
CD45, a protein-tyrosine phosphatase that is constitutively expressed on microglia [25], is markedly increased on microglia from AD frontal cortices [24], [32].
Positive_regulation (increased) of CD45 in microglia associated with disease
9) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.10 Pain Relevance 0
The CD11a(lo) population of splenocytes from the tick-infested mice was positive for TER-119 but negative for CD3, B220, CD11b and Gr, confirming that the splenocytes were members of the erythroid lineage.
Positive_regulation (negative) of B220
10) Confidence 0.32 Published 2005 Journal Ann Trop Med Parasitol Section Abstract Doc Link 16004711 Disease Relevance 0.33 Pain Relevance 0
Microglia were separated from macrophages/granulocytes based on CD45 expression, with intermediate levels of CD45 (CD45dim) identifying CD11b+ parenchymal microglia, and high levels of CD45 (CD45high) identifying CD11b+ macrophage/granulocytes [28].
Positive_regulation (levels) of CD45 in granulocytes
11) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.22 Pain Relevance 0
Quantification of inflammatory cells in wounds showed that allo-fibroblast- but not allo-BM-MSC-treated wounds had significantly increased CD45+ leukocytes, CD3+ lymphocytes and CD8+ T cells.
Positive_regulation (increased) of CD45 in leukocytes associated with inflammation and injury
12) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2743192 Disease Relevance 0.84 Pain Relevance 0.05
Besides the intense CD45 staining on cells of round appearance, a fainter immunostaining for CD45 was detected on cells with a more ramified appearance, indicating that, in addition to the recruitment of CD45+ cells into these areas, CD45 might also be upregulated on the resident microglial cells within the CVOs (Fig. 4, 5, 6).
Positive_regulation (upregulated) of CD45 in microglial cells
13) Confidence 0.30 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.22 Pain Relevance 0
Finally, since microglia become activated by stroke [14,20], and evidence shows that CD45 is inducible in microglia [29], we investigated whether cellular levels of CD45 expression were affected by the ischemic insult.
Positive_regulation (inducible) of CD45 in microglia associated with stroke
14) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.10 Pain Relevance 0
Indeed, MFI analysis showed that CD45 levels are upregulated in microglia 12–24 hours after pMCAO.
Positive_regulation (upregulated) of CD45 in microglia
15) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0.06
Similarly, CD45 levels were increased on infiltrating macrophages/granulocytes by 24 hours compared to unmanipulated control and sham-operated mice (Figure 4H).


Positive_regulation (increased) of CD45 in granulocytes
16) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0
We observed a significant upregulation of CD45 on microglia by 12 hours, which reached peak levels 24 hours after pMCAO compared to unmanipulated controls and sham-operated mice (Figure 4G).
Positive_regulation (upregulation) of CD45 in microglia
17) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.08 Pain Relevance 0
The membranes were blocked by phosphate buffered saline (PBS) containing 5% non-fat dried milk (w/v), 0.02% sodium azide, and 0.02% Tween 20 for 1 hr at room temperature, incubated at 4°C overnight with primary antibodies CD11b (Serotec, MCA711, Raleigh, NC) for detection of activated microglia, CD45 (Serotec, MCA1031G) for detection of migratory leukocytes or GFAP (Dako, Demark) for reactive astrocytes and visualized by the western lighting chemiluminescence reagent plus (Perkin Elmer, Boston, MA) according to the manufacturer's protocol.
Positive_regulation (activated) of CD45 in fat
18) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.08 Pain Relevance 0
and glial fibrillary acidic protein (GFAP) levels (Lim et al., 2000), and decreased expression of the microglial markers of activation CD45 and CD11b (Yan et al., 2003).
Positive_regulation (activation) of CD45
19) Confidence 0.17 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.72 Pain Relevance 0.21
Skeletal muscle interstitium-derived CD34+/CD45?
Positive_regulation (derived) of CD45 in Skeletal muscle
20) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.34 Pain Relevance 0

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