INT128496

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.40
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 98.44 Very High Very High Very High
chemokine 1 98.42 Very High Very High Very High
cytokine 29 98.18 Very High Very High Very High
Inflammatory mediators 7 97.76 Very High Very High Very High
addiction 5 96.28 Very High Very High Very High
pulpitis 2 81.24 Quite High
Osteoarthritis 112 80.00 Quite High
Inflammation 68 79.76 Quite High
Central nervous system 3 65.40 Quite High
Pain 15 51.20 Quite High
Disease Link Frequency Relevance Heat
Death 45 100.00 Very High Very High Very High
Apoptosis 89 99.84 Very High Very High Very High
Adhesions 2 98.62 Very High Very High Very High
INFLAMMATION 78 97.56 Very High Very High Very High
Cancer 59 86.28 High High
Breast Cancer 68 84.64 Quite High
Pulpitis 2 81.24 Quite High
Frailty 116 80.00 Quite High
Atherosclerosis 4 75.00 Quite High
Cardiovascular Disease 2 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.
Regulation (modulate) of caspase 1 associated with apoptosis
1) Confidence 0.38 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.12 Pain Relevance 0
The caspase-1 inhibitor YVAD significantly attenuated IL-1?
Regulation (The) of caspase-1
2) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.10
We also observed that various pro-inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostaglandin E(2) and its key enzyme COX-2, not iNOS or caspase-1, were markedly up-regulated by stimulation with these TLR and NOD agonists.
Regulation (regulated) of caspase-1 associated with chemokine, inflammatory mediators, agonist, adhesions and cytokine
3) Confidence 0.15 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.52 Pain Relevance 0.56
B may also work in a pro-apoptotic way by regulating 'interferon-regulated factor-1', the oncogene c-myc, p53 and caspase-1.
Regulation (regulating) of caspase-1 associated with apoptosis
4) Confidence 0.06 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.61 Pain Relevance 0
In addition to the role of caspases in the regulation and execution of cell death, caspase 1 (also termed IL-converting enzyme) is responsible for converting the precursors of IL-1 family cytokines IL-1?
Regulation (responsible) of caspase 1 associated with death and cytokine
5) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.54 Pain Relevance 0.19
In addition to the role of caspases in the regulation and execution of cell death, caspase 1 (also termed IL-converting enzyme) is responsible for converting the precursors of IL-1 family cytokines IL-1?
Regulation (regulation) of caspase 1 associated with death and cytokine
6) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.60 Pain Relevance 0.24

General Comments

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