INT128497

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.02
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
macrophages 2
cartilage 2
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Analgesic 1 98.72 Very High Very High Very High
Inflammation 8 98.44 Very High Very High Very High
cINOD 5 92.96 High High
Pain 2 91.12 High High
Angina 1 52.88 Quite High
ischemia 1 44.96 Quite Low
Inflammatory response 3 40.96 Quite Low
aspirin 1 31.04 Quite Low
analgesia 1 28.08 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 15 99.30 Very High Very High Very High
INFLAMMATION 11 98.44 Very High Very High Very High
Pain 1 91.12 High High
Adenovirus Infection 1 87.88 High High
Hypertension 2 80.88 Quite High
Pressure And Volume Under Development 2 79.52 Quite High
Atherosclerosis 4 75.00 Quite High
Cardiovascular Disease 2 68.72 Quite High
Stroke 1 68.08 Quite High
Rupture 2 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.
Regulation (modulate) of Gene_expression (expression) of caspase 1 associated with apoptosis
1) Confidence 0.38 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.13 Pain Relevance 0.05
The anti-inflammatory and analgesic effects of COX inhibition are reinforced through inhibition of caspase-1 regulated cytokine production, while nitric oxide donation provides multiorgan protection.
Regulation (regulated) of Gene_expression (production) of caspase-1 associated with inflammation, analgesic and cytokine
2) Confidence 0.35 Published 2006 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 16611049 Disease Relevance 0.73 Pain Relevance 0.66
The modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage specific matrix and proinflammatory enzymes were mediated in part by the cartilage-specific transcription factor Sox-9.
Regulation (effects) of Gene_expression (expression) of IL-1beta-induced in cartilage
3) Confidence 0.05 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0 Pain Relevance 0
As evidence that the inflammasome response operates independently of other known DNA-sensing mechanisms, it was shown that, following exposure to adenovirus DNA, caspase-1 processing was intact in macrophages that lack both TLR9 and the TLR adaptor protein MyD88.
Regulation (intact) of Gene_expression (processing) of caspase-1 in macrophages
4) Confidence 0.04 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.16 Pain Relevance 0

General Comments

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