INT128498

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.51
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
colon 1
HGF 1
T cell 1
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 94.68 High High
antagonist 6 78.00 Quite High
Inflammation 35 77.04 Quite High
Arthritis 3 72.20 Quite High
Rheumatism 1 71.76 Quite High
Taxol 1 71.36 Quite High
Neuritis 1 71.28 Quite High
Inflammatory response 1 64.00 Quite High
cINOD 12 52.24 Quite High
Angina 1 52.00 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 52 99.58 Very High Very High Very High
Apoptosis 192 99.30 Very High Very High Very High
Cancer 575 99.08 Very High Very High Very High
Breast Cancer 667 98.44 Very High Very High Very High
Prostate Cancer 162 98.08 Very High Very High Very High
Thyroid Neoplasm 2 95.60 Very High Very High Very High
Pain 2 94.68 High High
Stress 94 94.16 High High
Skin Cancer 14 93.88 High High
Neurodegenerative Disease 35 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, Barbash et al140 demonstrated that attenuation of cyclin D1 SCFFbx4 E3 ubiquitin ligase activity occurs frequently in human cancer and may represent a common mechanism of overexpression and deregulation of cyclin D1.
Regulation (deregulation) of cyclin D1 associated with cancer
1) Confidence 0.39 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.72 Pain Relevance 0
Apparently the frequency of cyclin D1 gene amplification (?
Regulation (frequency) of cyclin D1
2) Confidence 0.39 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.65 Pain Relevance 0
A subsequent colon cancer study, in which the effect of the CCND1 A870G polymorphism on colorectal cancer risk was found to be modified by GSTM1, GSTT1, and GSTP1 genotypes and ITC intake [141], further supports our proposed oxidative stress-based hypothesis.
Regulation (effect) of CCND1 in colon associated with stress and colon cancer
3) Confidence 0.34 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.81 Pain Relevance 0
While extracts of P. decumanum showed only moderate anti-cancer activity and were therefore not further analysed, particularly the dichloromethane extract of P. odorata inhibited the cell cycle in G2-M which correlated with the activation of checkpoint kinase 2, and down-regulation of Cdc25A and cyclin D1 as well as inactivation of Erk1/2.
Regulation (regulation) of cyclin D1 associated with cancer
4) Confidence 0.33 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.26 Pain Relevance 0.25
3), cell cycle (cyclin D1), arachidonic acid hydroxylation (cytochrome P450, family 4, subfamily F, polypeptide 12), cysteine protease inhibition (calpastatin), prolactin regulation (paired-like homeodomain 1) and a variety of cellular processes associated with G protein signaling (GTP-binding protein 10).
Regulation (regulation) of cyclin D1
5) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.74 Pain Relevance 0.09
Recent results on cyclin D1 (CCND1), an intracellular cell-cycle regulatory protein with checkpoint function, and breast cancer risk further support our hypothesis of an oxidative stress-induced apoptosis mechanism underlying the diet-induced breast cancer protection.
Regulation (results) of CCND1 associated with stress, breast cancer and apoptosis
6) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.96 Pain Relevance 0
Recent results on cyclin D1 (CCND1), an intracellular cell-cycle regulatory protein with checkpoint function, and breast cancer risk further support our hypothesis of an oxidative stress-induced apoptosis mechanism underlying the diet-induced breast cancer protection.
Regulation (results) of cyclin D1 associated with stress, breast cancer and apoptosis
7) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.96 Pain Relevance 0
Cyclin D1 (CCND1) was the only cyclin found to be deregulated, with a 2-fold lower expression level in all three therapy-resistant sublines.
Regulation (deregulated) of Cyclin D1
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
Cyclin D1 (CCND1) was the only cyclin found to be deregulated, with a 2-fold lower expression level in all three therapy-resistant sublines.
Regulation (deregulated) of CCND1
9) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0 Pain Relevance 0
MSMB, CCND1, EFNA3, FKBP and ADM, HGF are similarly regulated in mouse models and in our study [35-37].
Regulation (regulated) of CCND1 in HGF
10) Confidence 0.18 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.69 Pain Relevance 0.04
In addition, alterations in CDK1, CDK2, CDK4, cyclin D1 and cyclin E have been reported following exposure to PP [67,68,71].
Regulation (alterations) of cyclin D1
11) Confidence 0.15 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.39 Pain Relevance 0.06
B, STAT3 and their target cyclin D1 levels, as well as induction of Nrf2.
Regulation (target) of cyclin D1
12) Confidence 0.14 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.53 Pain Relevance 0
The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.
Regulation (modulate) of cyclin D1 associated with apoptosis
13) Confidence 0.12 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.13 Pain Relevance 0.05
This review summarizes mainly the prognostic values of classical (Ki67, ER, PR, HER2) and novel molecular factors (p53, p14ARF, cyclin D1, cyclin E, TBX2/3, BRCA1/2, and VEGF) for breast cancer.
Regulation (values) of cyclin D1 associated with breast cancer
14) Confidence 0.10 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.22 Pain Relevance 0
Indeed, cell cycle genes, including Wee-1, c-myc, and Cyclin-D1, are regulated in a circadian manner [77], further suggesting that the regular timing of these genes contributes to normal cell functioning.
Regulation (regulated) of Cyclin-D1
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995744 Disease Relevance 0.62 Pain Relevance 0
-catenin/T cell factor-4 tumor suppressor pathway, which is involved in the regulation of growth promoting genes such as c-myc and cyclin D1.
Regulation (regulation) of cyclin D1 in T cell associated with cancer
16) Confidence 0.07 Published 2003 Journal Comp Hepatol Section Abstract Doc Link PMC151270 Disease Relevance 0.65 Pain Relevance 0.03
The agent UBEIL has a remarkable effect on cyclin D1.
Regulation (effect) of cyclin D1
17) Confidence 0.04 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.22 Pain Relevance 0.05

General Comments

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