INT128499

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.15

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pigmentation (MC1R) peptidase activity (KLK7) extracellular region (KLK7)
plasma membrane (MC1R) signal transducer activity (MC1R)
KLK7 (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 78.96 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 1 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Soluble factors, such as proopiomelanocortin (POMC) derivatives, agouti signal protein (ASP) and others, regulate MC1R expression, leading to improved photoprotection via increased eumelanin synthesis or in contrast, inducing the switch to pheomelanin.
signal protein Regulation (regulate) of Gene_expression (expression) of MC1R
1) Confidence 0.01 Published 2005 Journal Peptides Section Abstract Doc Link 16005546 Disease Relevance 0.09 Pain Relevance 0.15

General Comments

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