INT1285

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.98
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
cartilage 3
chondrocytes 1
cardiomyocytes 1
vessels 1
extracellular matrix 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 338 100.00 Very High Very High Very High
cytokine 174 99.98 Very High Very High Very High
rheumatoid arthritis 276 99.90 Very High Very High Very High
Inflammatory mediators 27 99.56 Very High Very High Very High
cva 20 98.32 Very High Very High Very High
bradykinin 7 98.28 Very High Very High Very High
Inflammation 269 97.36 Very High Very High Very High
anesthesia 3 90.32 High High
Arthritis 154 89.56 High High
cINOD 3 88.52 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 14 99.92 Very High Very High Very High
Rheumatoid Arthritis 276 99.90 Very High Very High Very High
Fibrosis 99 99.84 Very High Very High Very High
INFLAMMATION 287 99.56 Very High Very High Very High
Hypercalcemia 5 99.32 Very High Very High Very High
Hemorrhage 14 98.32 Very High Very High Very High
Injury 76 97.66 Very High Very High Very High
Burns 24 97.52 Very High Very High Very High
Infection 64 96.80 Very High Very High Very High
Coagulation Disorder 1 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It induces osteoclast-mediated bone resorption (266), stimulates fibroblasts to secrete collagenase and prostaglandin E2 that in turn cause local soft tissue destruction (267), and may cause the resorption and inhibition of proteoglycans in cartilage (266-268).
Localization (secrete) of collagenase in cartilage associated with hypercalcemia
1) Confidence 0.78 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.15 Pain Relevance 0.17
Bacteria or bacterial products directly secrete collagenases or stimulate MMP production [69].
Localization (secrete) of collagenase
2) Confidence 0.78 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.77 Pain Relevance 0.45
The cartilage (triplicate cultures for each analytical point) was cultured for a total of 16 days and analyzed at day 16 for COL2A1 cleavage by collagenases and proteoglycan release.
Localization (release) of collagenase in cartilage
3) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.14 Pain Relevance 0.07
The triple-helical appearance of the immunogold label, and the sensitivity of the Mps1 and Polo localization to collagenase, are consistent with the underlying protein scaffold being a collagen-like protein.
Localization (localization) of collagenase
4) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2761730 Disease Relevance 0.12 Pain Relevance 0
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Localization (implicated) of MMP-13 associated with fibrosis
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Localization (secreted) of Mmp13 in extracellular matrix associated with metalloproteinase
6) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.41 Pain Relevance 0.11
acted synergistically with IL-1 to stimulate IL-1RA production and inhibit MMP-3 and MMP-13 release in human chondrocytes [38,39].
Localization (release) of MMP-13 in chondrocytes associated with metalloproteinase
7) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.53 Pain Relevance 0.51
reduced MMP-13 secretion to 0.8 ± 0.1 ng/ml and 0.4 ± 0.08 ng/ml at 24 and 72 hours respectively.
Localization (secretion) of MMP-13 associated with metalloproteinase
8) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.63 Pain Relevance 1.00
Of note, however, RA FLS secreted >100 fold more MMP-1 than MMP-13 under the same in vitro conditions, implying that perhaps production of MMP-1 by FLS is more important than that of MMP-13 in catalysing cartilage degradation in RA.
Localization (secreted) of MMP-13 in cartilage associated with metalloproteinase and rheumatoid arthritis
9) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.74 Pain Relevance 1.09
Mice were killed 24 h post-burn to determine presence of partial-thickness or full-thickness burn injury, cardiac contractile function (Langendorff perfusion, n = 7 or 8 mice/group) or to examine cardiac myocyte cytokine secretion in isolated cardiomyocytes (collagenase perfusion, n = 4 or 5 mice/group).
Spec (examine) Localization (secretion) of collagenase in cardiomyocytes associated with burns, injury and cytokine
10) Confidence 0.15 Published 2001 Journal Shock Section Abstract Doc Link 11508864 Disease Relevance 1.83 Pain Relevance 0.18
Thus, PSCs have been shown to secrete MMP-2, MMP-9 and MMP-13 and to express TIMP-1 and TIMP-2 [73].
Localization (secrete) of MMP-13
11) Confidence 0.08 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.52 Pain Relevance 0.24
Then proteolytic enzymes expressed in osteoclasts, such as cathepsin K and MMPs (MMP-13, MMP-2 and MMP-9), are secreted into the lacuna for removal of bone mineral and degradation of organic matrix protein [32].
Localization (secreted) of MMP-13 in lacuna associated with metalloproteinase
12) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.23 Pain Relevance 0.21
Collagenase did not increase permeability of rat skin vessels, nor did it release potential inflammatory mediators, such as bradykinin or prostaglandins, from plasma or platelets.
Localization (release) of Collagenase in vessels associated with inflammatory mediators and bradykinin
13) Confidence 0.03 Published 1976 Journal Agents Actions Section Abstract Doc Link 184702 Disease Relevance 1.01 Pain Relevance 0.59

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