INT128516

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.96
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fmod) extracellular region (Fmod) proteinaceous extracellular matrix (Fmod)
intracellular (Fmod)
Anatomy Link Frequency
ECM 2
cartilage 1
temporomandibular joint 1
Fmod (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 32 99.36 Very High Very High Very High
Osteoarthritis 17 98.40 Very High Very High Very High
Pain 3 92.00 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 32 99.36 Very High Very High Very High
Osteoarthritis 17 98.40 Very High Very High Very High
Disease 6 95.16 Very High Very High Very High
Pain 3 92.00 High High
Apoptosis 9 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate whether the absence of biglycan and fibromodulin, two proteoglycans expressed in cartilage, bone and tendon, resulted in accelerated osteoarthritis in the temporomandibular joint (TMJ).
Spec (whether) Negative_regulation (absence) of fibromodulin in cartilage associated with snapping jaw and osteoarthritis
1) Confidence 0.43 Published 2005 Journal Osteoarthr. Cartil. Section Abstract Doc Link 16006154 Disease Relevance 0.34 Pain Relevance 0.26
We present in greater detail one animal model that is deficient in two extracellular matrix (ECM) proteoglycans, biglycan (BGN) and fibromodulin (FMOD).
Negative_regulation (deficient) of FMOD in ECM
2) Confidence 0.42 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.55 Pain Relevance 0.98
We present in greater detail one animal model that is deficient in two extracellular matrix (ECM) proteoglycans, biglycan (BGN) and fibromodulin (FMOD).
Negative_regulation (deficient) of fibromodulin in ECM
3) Confidence 0.42 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.55 Pain Relevance 0.98
Mice deficient in biglycan and fibromodulin as a model for temporomandibular joint osteoarthritis.
Negative_regulation (deficient) of fibromodulin in temporomandibular joint associated with snapping jaw and osteoarthritis
4) Confidence 0.42 Published 2005 Journal Cells Tissues Organs (Print) Section Title Doc Link 16612079 Disease Relevance 1.51 Pain Relevance 0.98

General Comments

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