INT128546

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 98.16 Very High Very High Very High
dexamethasone 23 94.80 High High
cINOD 4 72.88 Quite High
Multiple sclerosis 17 62.72 Quite High
Inflammatory mediators 3 56.64 Quite High
Central nervous system 7 11.04 Low Low
cytokine 7 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 17 100.00 Very High Very High Very High
Multiple Sclerosis 50 99.48 Very High Very High Very High
INFLAMMATION 35 98.16 Very High Very High Very High
Apoptosis 40 90.68 High High
Aging 49 63.60 Quite High
Disease 45 56.16 Quite High
Obesity 51 46.52 Quite Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following gene products emerged as hubs: Fos, a transcription factor involved in stress response; glucocorticoid receptor (encoded by Nr3c1), involved in stress response and inflammation; RhoA, an important signaling molecule associated with cytoskeletal remodeling; and Cdkn1b, which maintains cell cycle arrest.
glucocorticoid receptor Binding (emerged) of associated with stress and inflammation
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.74 Pain Relevance 0.05
Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial activities mediated by transrepression but avoid adverse effects of GR action requiring transactivation.
glucocorticoid receptor Binding (Dissociating) of associated with inflammation
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781169 Disease Relevance 0.51 Pain Relevance 0.14
Mechanistic studies in H441 cells revealed that glucocorticoids, acting via the glucocorticoid receptor, increase C/EBPbeta binding starting 10 min after stimulation.
glucocorticoid receptor Binding (binding) of
3) Confidence 0.05 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16009338 Disease Relevance 0.15 Pain Relevance 0.11
In particular, they obtained a comprehensive map of glucocorticoid receptor binding to DNA overall the genome by ChIP-Seq, and measured related changes in gene expression by RNA-Seq, in response to treatment with dexamethasone [125].
glucocorticoid receptor Binding (binding) of associated with dexamethasone
4) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0 Pain Relevance 0.05

General Comments

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