INT128552

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.50
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IFI44)
Anatomy Link Frequency
arms 1
BxPC-3 1
IFI44 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 98.92 Very High Very High Very High
agonist 22 5.00 Very Low Very Low Very Low
Chronic pancreatitis 14 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
Clonidine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 357 99.76 Very High Very High Very High
Inflammatory Breast Neoplasms 14 99.20 Very High Very High Very High
Metastasis 161 98.52 Very High Very High Very High
Cancer 223 97.72 Very High Very High Very High
Disease 20 84.40 Quite High
Pancreatic Cancer 49 75.36 Quite High
Carcinoma 7 65.52 Quite High
Contagious Ecthyma 5 59.64 Quite High
Brucella Infection 1 58.72 Quite High
Ehrlichiosis 23 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histamine induced a time-dependent, H1 receptor-mediated activation of p38 MAP kinase (p38), p44/42 MAP kinase (ERK), and c-jun terminal NH2 kinase (JNK).
Positive_regulation (activation) of p44
1) Confidence 0.45 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
The annotated p44 fragments are at least 60 nucleotides in length, have either 5?
Positive_regulation (annotated) of p44
2) Confidence 0.27 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.18 Pain Relevance 0
This could potentially explain why PC cells harboring activating K-Ras mutations have lower activated phospho-p42/p44 Erk levels than expected [41,42].
Positive_regulation (activated) of p44 associated with adenocarcinoma
3) Confidence 0.19 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.51 Pain Relevance 0.03
Our laboratory has previously demonstrated that RhoC can mediate inflammatory breast cancer cell migration and invasion through co-activation of the p42/p44 Erk and p38 arms of the MAPK pathway [40].
Positive_regulation (activation) of p44 in arms associated with inflammation
4) Confidence 0.19 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0.05
Previous studies demonstrated that activation of p42/p44 extracellular regulated kinase (Erk) decreased cav-1 protein levels in constitutively-active Ras transformed NIH3T3 cells [38].
Positive_regulation (activation) of p44
5) Confidence 0.19 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0.03
LPA and S1P each stimulated p44/42 ERK phosphorylation relative to total p44/42 ERK protein, with peak phosphorylation occurring after 5 minutes of stimulation, followed by a later sustained lower level of phosphorylation at 30–60 minutes (Figure 6).
Positive_regulation (total) of p44
6) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
LPA and S1P each stimulated p44/42 ERK phosphorylation relative to total p44/42 ERK protein, with peak phosphorylation occurring after 5 minutes of stimulation, followed by a later sustained lower level of phosphorylation at 30–60 minutes (Figure 6).
Positive_regulation (stimulated) of p44
7) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
High cav-1 expression is associated with higher levels of active p42/p44 irregardless of K-Ras mutational status.
Positive_regulation (levels) of p44
8) Confidence 0.12 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.67 Pain Relevance 0.04
Further, expression of cav-1 favors activation of the p42/p44 Erk pathway, perhaps promoting growth and survival.
Positive_regulation (activation) of p44
9) Confidence 0.12 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.75 Pain Relevance 0.03
Experiments in NIH3T3 and CHO cells suggest a reciprocal and reversible relationship between p42/p44 Erk activation and cav-1 expression [38,39].
Positive_regulation (activation) of p44
10) Confidence 0.12 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.80 Pain Relevance 0.05
Comparison of the BxPC-3 (derived from a primary tumor) and HPAF-II (derived from a metastasis) demonstrates a reciprocal relationship between cav-1 expression and p42/p44 Erk activation with PC cell migration, invasion, RhoC GTPase and p38 MAPK activation.
Positive_regulation (activation) of p44 in BxPC-3 associated with adenocarcinoma, cancer and metastasis
11) Confidence 0.12 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 1.18 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox