INT128587

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Context Info
Confidence 0.81
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 8.41
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
neurons 2
hairs 2
spinal cord 1
brain 1
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 200 100.00 Very High Very High Very High
cytokine 60 99.96 Very High Very High Very High
sodium channel 5 99.90 Very High Very High Very High
Opioid 4 99.84 Very High Very High Very High
Analgesic 18 99.80 Very High Very High Very High
Pain 71 99.72 Very High Very High Very High
Eae 54 99.32 Very High Very High Very High
Spinal cord 103 98.84 Very High Very High Very High
intrathecal 112 97.98 Very High Very High Very High
Cancer pain 2 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 205 100.00 Very High Very High Very High
Bone Cancer 2 98.08 Very High Very High Very High
Cancer Pain 2 97.88 Very High Very High Very High
Apoptosis 76 97.52 Very High Very High Very High
Neuropathic Pain 152 97.38 Very High Very High Very High
Disease 12 96.04 Very High Very High Very High
Autoimmune Disease 14 94.68 High High
Arthritis 44 93.48 High High
Inflammatory Pain 14 92.44 High High
Cancer 12 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated p38 was only colocalized with the microglial surface marker OX-42, indicating a microglial localization of phosphorylated p38 in the SNI model.
Localization (localization) of p38
1) Confidence 0.81 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.06 Pain Relevance 0
We assessed mechanical allodynia, hypoalgesia, and motor function using von Frey hairs, treadmill tests, and immunohistochemical localization of phosphorylated p38 (P-p38) in the cauda equina, dorsal root ganglion (DRG), and spinal cord, which were also double-stained with NeuN (neuronal marker), GFAP (astrocyte/Schwann cell marker), or isolectin B4 (IB4; microglia marker).
Localization (localization) of p38 in hairs
2) Confidence 0.75 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
We assessed mechanical allodynia, hypoalgesia, and motor function using von Frey hairs, treadmill tests, and immunohistochemical localization of phosphorylated p38 (P-p38) in the cauda equina, dorsal root ganglion (DRG), and spinal cord, which were also double-stained with NeuN (neuronal marker), GFAP (astrocyte/Schwann cell marker), or isolectin B4 (IB4; microglia marker).
Localization (localization) of p38 in hairs
3) Confidence 0.75 Published 2007 Journal Spine Section Body Doc Link 17224809 Disease Relevance 0 Pain Relevance 0
[The cellular location and significance of p38alpha/beta isoforms in the lumbar spinal cord of the bone cancer pain rats].
Localization (location) of p38alpha in spinal cord associated with pain, cancer pain, bone cancer and spinal cord
4) Confidence 0.73 Published 2007 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 17403314 Disease Relevance 0.20 Pain Relevance 0.59
Serial sections and/or double staining of the same section were used to determine colocalization of phosphorylated p38 (P-p38) (1:500, Cell Signaling Technology, Beverly, Massachusetts, United States) with cell markers OX42 (1:100, Biosource International, Camarillo, Texas, United States) for microglia and NeuN (1:1,000, Chemicon, Temecula, California, United States) for neurons.
Spec (determine) Localization (colocalization) of p38 in neurons
5) Confidence 0.71 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.20 Pain Relevance 0.13
Serial sections and/or double staining of the same section were used to determine colocalization of phosphorylated p38 (P-p38) (1:500, Cell Signaling Technology, Beverly, Massachusetts, United States) with cell markers OX42 (1:100, Biosource International, Camarillo, Texas, United States) for microglia and NeuN (1:1,000, Chemicon, Temecula, California, United States) for neurons.
Spec (determine) Localization (colocalization) of p38 in neurons
6) Confidence 0.71 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.20 Pain Relevance 0.13
We show in this study that sodium channels and p38 MAP kinase colocalize in rat brain tissue and that activated p38alpha phosphorylates L1 of Nav1.6, specifically at serine 553 (S553), in vitro.
Localization (colocalize) of p38 in brain associated with sodium channel and nav1.6
7) Confidence 0.50 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014723 Disease Relevance 0.25 Pain Relevance 0.98
CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo.
Localization (release) of p38 associated with opioid
8) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Title Doc Link 17604950 Disease Relevance 0.28 Pain Relevance 0.90
the presence of insulin and stimulates p38 MAP-kinase and PI-3 kinase activity
Localization (presence) of p38 MAP-kinase
9) Confidence 0.29 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.56 Pain Relevance 0.06
Phosphorylated p38 is localized in small TNF-?
Localization (localized) of p38
10) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.51 Pain Relevance 1.04
Three mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase, (ERK) and p38 kinase (p38), were investigated using Western immunoblots.
Localization (kinase) of p38
11) Confidence 0.21 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.07 Pain Relevance 0
Three mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase, (ERK) and p38 kinase (p38), were investigated using Western immunoblots.
Localization (kinase) of p38
12) Confidence 0.21 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 1.07 Pain Relevance 0
Topical piroxicam in vitro release and in vivo anti-inflammatory and analgesic effects from palm oil esters-based nanocream

Introduction

Localization (release) of anti-inflammatory associated with inflammation and analgesic
13) Confidence 0.10 Published 2010 Journal Int J Nanomedicine Section Title Doc Link PMC2990385 Disease Relevance 0.32 Pain Relevance 0.36
The various MAPKs, especially ERK2 and p38 are known to be activated by ACs, and in rare cases (though sometimes reciprocal) even JNK.
Localization (reciprocal) of p38
14) Confidence 0.09 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.09 Pain Relevance 0.08
A number of drugs targeting the kinases p38, JNK, MEK, IKK2, JAK3, Lck, and Syk are currently undergoing clinical trials for the treatment of diseases related to inflammation and autoimmunity.
Localization (targeting) of p38 associated with autoimmune disease, inflammation and disease
15) Confidence 0.08 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.96 Pain Relevance 0.22
The purpose of the present series of studies was to explore a new approach to neuropathic pain control; that is, intrathecal gene therapy using an adeno-associated viral (serotype II; AAV2) vector to drive the production and release of interleukin-10 (IL-10), a powerful anti-inflammatory cytokine [19].
Localization (release) of anti-inflammatory associated with inflammation, neuropathic pain, cytokine and intrathecal
16) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 1.92 Pain Relevance 1.62
B binding activity, ERK and p-38-dependent cytochrome c release, and caspase-3 activation [22-24].
Localization (release) of p-38-dependent
17) Confidence 0.01 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.72 Pain Relevance 0

General Comments

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