INT12859

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Context Info
Confidence 0.32
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 2.68
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
neurons 3
primary neurons 1
tail 1
nucleus 1
forebrain 1
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 96 100.00 Very High Very High Very High
opioid receptor 39 100.00 Very High Very High Very High
mu opioid receptor 5 100.00 Very High Very High Very High
gABA 5 100.00 Very High Very High Very High
Glutamate receptor 3 100.00 Very High Very High Very High
antagonist 21 99.96 Very High Very High Very High
Pain 58 99.80 Very High Very High Very High
Bile 18 99.68 Very High Very High Very High
Enkephalin 29 99.50 Very High Very High Very High
Dynorphin 9 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 61 99.80 Very High Very High Very High
Targeted Disruption 31 99.38 Very High Very High Very High
Apoptosis 6 98.02 Very High Very High Very High
Bordatella Infection 1 90.56 High High
Death 4 88.64 High High
Convulsion 4 82.88 Quite High
Toxicity 2 82.76 Quite High
Anxiety Disorder 1 79.32 Quite High
Ganglion Cysts 1 78.80 Quite High
Inflammatory Pain 32 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-Phe-Cys-Tyr-D-Try-Orn-Thr-Pen-Thr-NH2 (CTOP; 0.5 microgram) and beta-funaltrexamine (beta-FNA; 2.5 micrograms), selective mu opioid receptor antagonists, and ICI 174,864 (10 micrograms), a delta-opioid receptor antagonist, which blocked the effects induced by DAMGO (16 ng) and DPDPE (20 micrograms), respectively, did not block inhibition of the tail-flick response induced by bremazocine (1 microgram) given i.c.v.
Localization (selective) of receptor in tail associated with antagonist, tail-flick, mu opioid receptor and opioid receptor
1) Confidence 0.32 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1656027 Disease Relevance 0 Pain Relevance 0.77
Bile and pancreatic secretions were determined in a CCK-A receptor deficient mouse mutant generated by gene targeting in embryonic stem cells.
Spec (determined) Localization (secretions) of receptor in embryonic stem cells associated with bile
2) Confidence 0.24 Published 2001 Journal Jpn. J. Physiol. Section Abstract Doc Link 11734079 Disease Relevance 0.07 Pain Relevance 0.25
Neuromedin C and acetylcholine increased amylase secretion in CCK-A receptor (-/-) mice similar to (+/-) and (+/+) mice.
Localization (secretion) of receptor
3) Confidence 0.24 Published 2001 Journal Jpn. J. Physiol. Section Abstract Doc Link 11734079 Disease Relevance 0.07 Pain Relevance 0.31
Importance of CCK-A receptor for gallbladder contraction and pancreatic secretion: a study in CCK-A receptor knockout mice.
Localization (secretion) of receptor associated with targeted disruption
4) Confidence 0.23 Published 2001 Journal Jpn. J. Physiol. Section Title Doc Link 11734079 Disease Relevance 0.10 Pain Relevance 0.32
Therefore, it may be suggested that tramadol exerts a seizurogenic effect on mice via an H(1) receptor activation-linked pathway possibly through an opioid receptor-dependent release of histamine from the mast cells.
Localization (release) of receptor in mast cells associated with tramadol and opioid receptor
5) Confidence 0.20 Published 2010 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 20012267 Disease Relevance 0.44 Pain Relevance 0.60
These analyses revealed that the degranulation is mediated by putative metabotropic neurosteroid receptor, G(q/11), phospholipase C and Ca(2+) mobilization from intracellular stores.
Localization (mobilization) of neurosteroid receptor
6) Confidence 0.11 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16381660 Disease Relevance 0.18 Pain Relevance 0.15
Late postnatal reorganization of GABA(A) receptor signalling in native GnRH neurons.
Localization (reorganization) of ) receptor in neurons associated with gaba
7) Confidence 0.10 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.17
Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice.
Localization (localized) of receptor in forebrain associated with glutamate receptor and morphine
8) Confidence 0.04 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15355330 Disease Relevance 0 Pain Relevance 0.66
Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation.
Localization (release) of receptor in neurons associated with dynorphin and apoptosis
9) Confidence 0.03 Published 2003 Journal Neuroscience Section Title Doc Link 14643768 Disease Relevance 0.47 Pain Relevance 0.76
M(1) receptor antagonism with pirenzepine, nitric oxide (NO) synthase inhibition with N(omega)-nitro-L-arginine methyl ester hydrochloride, and inhibition of neuronal activation with tetrodotoxin abolished relaxation to McN-A-343 in tissues from M(3) receptor knockout mice, supporting the neuronal localization of an M(1) receptor that activated NO release to effect relaxation.
Localization (localization) of receptor in neuronal associated with targeted disruption and tetrodotoxin
10) Confidence 0.03 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538821 Disease Relevance 0.26 Pain Relevance 0.14
Co-localization of CART peptide and CCK-A receptor in vagal afferent neurons suggested that CART peptide might take part in mediating satiety effects of cholecystokinin [23].
Localization (localization) of receptor in afferent neurons associated with cholecystokinin
11) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.28 Pain Relevance 0.89
Similarly, our initial examination of primary neurons from DOR-eGFP mice, showed that Met-enkephalin and SNC80 trigger rapid internalization of the fluorescent receptor [13].
Localization (internalization) of receptor in primary neurons associated with enkephalin
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0 Pain Relevance 0.58
Overall these results establish that, in the context of pain control, receptor localization fully controls receptor function in vivo.
Localization (localization) of receptor associated with pain
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.73
Overall these results establish that, in the context of pain control, receptor localization fully controls receptor function in vivo.
Localization (localization) of receptor associated with pain
14) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2672171 Disease Relevance 0.15 Pain Relevance 0.76
In this study, we used knock-in mice expressing functional fluorescent delta opioid receptors (DOR-eGFP) in place of the native receptor to correlate receptor localization in neurons with behavioral responses.
Localization (localization) of receptor in neurons associated with targeted disruption and delta opioid receptors
15) Confidence 0.02 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2672171 Disease Relevance 0.27 Pain Relevance 0.51
By radioimmunoassay (RIA), 32 cell lines have been detected that secrete an antibody to a component of the isolated receptor complex.
Localization (secrete) of receptor
16) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319852 Disease Relevance 0.05 Pain Relevance 0.42
The activated receptor Smads form a complex with the co-Smad, Smad4 - this complex translocates to the nucleus and modifies gene expression.
Localization (translocates) of receptor in nucleus
17) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.18 Pain Relevance 0.06

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