INT128595

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
olfactory tubercle 2
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 98.76 Very High Very High Very High
nMDA receptor 1 90.60 High High
alcohol 4 85.84 High High
Glutamate 3 75.84 Quite High
antagonist 3 75.00 Quite High
Spinal cord 2 50.00 Quite Low
Morphine 2 50.00 Quite Low
Glutamate receptor 2 50.00 Quite Low
depression 1 48.68 Quite Low
Pain 1 47.24 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 82.60 Quite High
Depression 2 79.28 Quite High
Sprains And Strains 3 75.00 Quite High
Sleep Disorders 1 67.60 Quite High
Pain 1 47.24 Quite Low
Alcohol Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic MTEP also caused a significant decrease in mGlu5 gene expression and a significant increase in dopamine transporter and dopamine D(2)-like receptor binding within the olfactory tubercle.
Negative_regulation (decrease) of Gene_expression (expression) of mGlu5 gene in olfactory tubercle associated with dopamine
1) Confidence 0.38 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.51 Pain Relevance 0.43
MPEP plays its role in morphine tolerance by partly inhibiting the expression of mGluRS.


Negative_regulation (inhibiting) of Gene_expression (expression) of mGluRS
2) Confidence 0.38 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20058604 Disease Relevance 0 Pain Relevance 0

General Comments

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