INT128609

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 17.36
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1S) extracellular region (C1S)
Anatomy Link Frequency
liver 3
intestine 2
plasma 1
ciliary body 1
iris 1
C1S (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 16 92.72 High High
Angina 14 89.44 High High
cytokine 5 80.44 Quite High
bradykinin 20 78.88 Quite High
Inflammatory mediators 2 69.84 Quite High
Bile 66 46.96 Quite Low
potassium channel 2 30.56 Quite Low
antagonist 5 11.88 Low Low
Inflammation 26 7.76 Low Low
cva 46 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1066 100.00 Very High Very High Very High
Disease 288 100.00 Very High Very High Very High
Cardiovascular Disease 76 99.76 Very High Very High Very High
Hypertension 30 99.38 Very High Very High Very High
Acute Coronary Syndrome 4 99.36 Very High Very High Very High
Pseudomyxoma Peritonei 13 99.16 Very High Very High Very High
Dystonia 11 98.76 Very High Very High Very High
Dengue 208 98.72 Very High Very High Very High
Convulsion 8 98.24 Very High Very High Very High
Coronary Artery Disease 387 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HDL-C is synthesized in the intestine and liver and is extremely important in reverse cholesterol transport from the tissues to the liver for disposal.
Gene_expression (synthesized) of C is in intestine associated with disorder of lipid metabolism
1) Confidence 0.75 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC544835 Disease Relevance 1.42 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Gene_expression (produced) of C is in plasma associated with disorder of lipid metabolism
2) Confidence 0.75 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.16 Pain Relevance 0
Primary care providers treat high-risk patients relatively aggressively; however, opportunities to forestall cardiovascular disease may be missed in hypertensive, dyslipidemic women whose LDL-C is often not measured and controlled.
Neg (not) Gene_expression (measured) of C is associated with cardiovascular disease and hypertension
3) Confidence 0.65 Published 2005 Journal J Clin Hypertens (Greenwich) Section Abstract Doc Link 16015048 Disease Relevance 0.84 Pain Relevance 0.59
NP-C is transmitted in an autosomal recessive manner and is caused by mutations of either the NPC1 (95% of families) or the NPC2 genes.
Gene_expression (transmitted) of C is associated with disease
4) Confidence 0.65 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2902432 Disease Relevance 1.68 Pain Relevance 0
Serum HDL-C is divided in three levels of risk; <35, 35–59, and ?
Gene_expression (Serum) of C is associated with disorder of lipid metabolism
5) Confidence 0.65 Published 2009 Journal Trials Section Body Doc Link PMC2656492 Disease Relevance 0.92 Pain Relevance 0.05
Serum HDL-C is divided in three levels of risk; <35, 35–59, and ?
Gene_expression (divided) of C is associated with disorder of lipid metabolism
6) Confidence 0.65 Published 2009 Journal Trials Section Body Doc Link PMC2656492 Disease Relevance 0.92 Pain Relevance 0.05
It is commonly thought that a desirable ratio of LDL-C/HDL-C is 3.5, which has been used as an indicator of coronary atherosclerosis [33].
Gene_expression (/) of C is associated with coronary artery disease and disorder of lipid metabolism
7) Confidence 0.65 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.74 Pain Relevance 0
IPHC with mitomycin C is used for all patients with PMP.
Gene_expression (used) of C is associated with pseudomyxoma peritonei
8) Confidence 0.65 Published 2006 Journal J Transl Med Section Body Doc Link PMC1481500 Disease Relevance 1.01 Pain Relevance 0
In a pioneering study, Bokisch et al. [3] measured the levels of nine complement factors (C1q, C1s, C2, C3, C4, C5, C6, C8 and factor B) in serum samples of DHF patients (grades I to IV).
Gene_expression (levels) of C1s associated with flavivirus infection
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.42 Pain Relevance 0
However, neither the levels of C1q and C1s, nor the catabolic rate of C1q degradation presented a significant correlation with disease severity [3].
Gene_expression (levels) of C1s associated with disease
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.10 Pain Relevance 0
VLDL-C is synthesized in the liver in response to a high carbohydrate diet.
Gene_expression (synthesized) of C is in liver
11) Confidence 0.58 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.83 Pain Relevance 0
Most of the early classical pathway complement genes, including C1 components (C1S, C1QA, C1QG, C1R), C2, and C4b, as well as a component of the late complement cascade (C7), were selectively expressed in both the corneal and ciliary body/iris tissues.
Gene_expression (expressed) of C1S in iris
12) Confidence 0.45 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.18 Pain Relevance 0.11
Complement system activation, in particular, would deplete C1-inhibitor because C1r and C1s are present in greater quantities than most of the other proteases and because complement activation in HAE tends to be extensive.
Gene_expression (present) of C1s associated with hereditary angioedema
13) Confidence 0.42 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.15 Pain Relevance 0.07
HDL-C is synthesized in the intestine and liver and is extremely important in reverse cholesterol transport from the tissues to the liver for disposal.
Gene_expression (synthesized) of C is in liver associated with disorder of lipid metabolism
14) Confidence 0.26 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC544835 Disease Relevance 1.42 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Gene_expression (produced) of C is in intestine associated with disorder of lipid metabolism
15) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.16 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Gene_expression (produced) of C is in liver associated with disorder of lipid metabolism
16) Confidence 0.26 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.16 Pain Relevance 0
Thus we believe that expression signals of the twelve human and rat orthologs, except for the gene C1S, obtained by Affymetrix chips used in these studies could accurately measure mRNA abundance of the twelve genes in the human and rat samples.
Gene_expression (expression) of C1S
17) Confidence 0.16 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.06 Pain Relevance 0
Most of the early classical pathway complement genes, including C1 components (C1S, C1QA, C1QG, C1R), C2, and C4b, as well as a component of the late complement cascade (C7), were selectively expressed in both the corneal and ciliary body/iris tissues.
Gene_expression (expressed) of C1S in ciliary body
18) Confidence 0.15 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.18 Pain Relevance 0.11

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