INT12861

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 40
Total Number 41
Disease Relevance 23.01
Pain Relevance 8.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Anatomy Link Frequency
SH2 1
joint 1
RVM 1
tail 1
bladder 1
Cish (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 952 100.00 Very High Very High Very High
Multiple sclerosis 671 100.00 Very High Very High Very High
tail-flick 12 99.40 Very High Very High Very High
antinociception 19 98.96 Very High Very High Very High
Inflammation 95 98.52 Very High Very High Very High
intrathecal 6 98.32 Very High Very High Very High
Action potential 1 98.16 Very High Very High Very High
tetrodotoxin 1 97.40 Very High Very High Very High
palliative 12 97.04 Very High Very High Very High
Pyramidal cell 2 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Demyelinating Disease 793 100.00 Very High Very High Very High
Sepsis 666 100.00 Very High Very High Very High
Syndrome 264 100.00 Very High Very High Very High
Carcinoma In Situ 20 100.00 Very High Very High Very High
Cancer 22 99.78 Very High Very High Very High
INFLAMMATION 96 98.52 Very High Very High Very High
Carcinoma 2 97.60 Very High Very High Very High
Disease 218 97.24 Very High Very High Very High
Encephalitis 10 97.24 Very High Very High Very High
Bladder Cancer 4 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disease modifying drugs, in particular interferons-beta, have been shown to reduce the risk of MS conversion in high-risk patients presenting with a CIS.
Gene_expression (presenting) of CIS
1) Confidence 0.57 Published 2008 Journal Neurologist Section Body Doc Link 18617847 Disease Relevance 0.15 Pain Relevance 0
Despite huge variations in the levels of provision across the countries of CEE and the CIS, data collected in the qualitative survey reveal that the development of palliative care in many countries continues to remain uneven, uncoordinated, and poorly integrated across wider health care systems, mainly as a result of inadequate investment and limited palliative care service capacity.
Gene_expression (countries) of CIS associated with palliative
2) Confidence 0.51 Published 2009 Journal J Pain Symptom Manage Section Abstract Doc Link 19268812 Disease Relevance 0 Pain Relevance 1.03
Seven days after surgical implantation of intrathecal catheters, animals were injected with graded doses of (+)-cis-methyldioxolane. (+)-cis-Methyldioxolane produced hot-plate and tail-flick antinociception for up to 90 min, peaking 5 to 30 min after injection.
Gene_expression (produced) of cis-Methyldioxolane in tail associated with antinociception, tail-flick and intrathecal
3) Confidence 0.51 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8101218 Disease Relevance 0.17 Pain Relevance 0.85
The enantiomers of cis-cromakalim were synthesized and their biological activity compared to that of the enantiomers of (trans-)cromakalim.
Gene_expression (synthesized) of cis-cromakalim
4) Confidence 0.38 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8491256 Disease Relevance 0 Pain Relevance 0.07
These differences in SOCS expression appeared independent of the induction of mRNA of the GHR or of IGF-I.
Gene_expression (expression) of SOCS
5) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.40 Pain Relevance 0.14
While differences in cytokine levels were observed, any mechanistic influence of these on SOCS expression cannot be determined from the present study.
Gene_expression (expression) of SOCS associated with cytokine
6) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.62 Pain Relevance 0.13
The mechanism of the increase in SOCS expression in abdominal sepsis is unknown, and the authors of the study commented that the time course observed was consistent with that produced by endotoxin and inflammatory cytokines.
Gene_expression (expression) of SOCS associated with inflammation, sepsis and cytokine
7) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.43 Pain Relevance 0.13
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Gene_expression (expression) of CIS associated with sepsis
8) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.11
Yumet and colleagues [13] have recently shown in rats with abdominal sepsis that total GHR numbers are unchanged, with the impaired IGF-I response to GH being temporally related to a defect in STAT5 activation and increased SOCS mRNA expression.
Gene_expression (expression) of SOCS mRNA associated with sepsis
9) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.46 Pain Relevance 0.11
In light of the previous study that demonstrated an effect of PN on CIS expression [14], we were particularly interested in the possibility that nutrition, and possibly the route of feeding, might influence SOCS expression and thus GH resistance.
Gene_expression (expression) of SOCS
10) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.53 Pain Relevance 0.10
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Gene_expression (expression) of SOCS associated with sepsis
11) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.11
As seen in the prior study, however, SOCS-2 expression was not affected by sepsis [14].
Gene_expression (expression) of SOCS associated with sepsis
12) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.13
Hepatic mRNA of CIS, SOCS-2 and SOCS-3 is transiently increased following endotoxin administration [31], while SOCS-1 expression and SOCS-3 expression were found to be increased 24 hours following CLP [14].
Gene_expression (expression) of SOCS
13) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.41 Pain Relevance 0.13
Conclusions were that primary CIs were present in 34% of 100 consecutive patients, mainly owing to dental problems.
Gene_expression (present) of CIs
14) Confidence 0.32 Published 2002 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12153957 Disease Relevance 0.54 Pain Relevance 0.24
In animals with sepsis, the CIS expression was increased by EN, and SOCS-2 expression was greater in sham-operated animals than septic animals given PN.
Gene_expression (expression) of CIS associated with sepsis
15) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.48 Pain Relevance 0.13
In light of the previous study that demonstrated an effect of PN on CIS expression [14], we were particularly interested in the possibility that nutrition, and possibly the route of feeding, might influence SOCS expression and thus GH resistance.
Gene_expression (expression) of CIS
16) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.58 Pain Relevance 0.08
SOCS-1 and CIS expression were increased 4 hours following induction of sepsis, but by 24 hours were no different from measurements in sham-operated animals – whereas SOCS-3 expression remained elevated at 24 hours.
Gene_expression (expression) of SOCS associated with sepsis
17) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.49 Pain Relevance 0.12
Hepatic mRNA of CIS, SOCS-2 and SOCS-3 is transiently increased following endotoxin administration [31], while SOCS-1 expression and SOCS-3 expression were found to be increased 24 hours following CLP [14].
Gene_expression (expression) of SOCS
18) Confidence 0.30 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.41 Pain Relevance 0.13
Results are expressed as ORs and 95% CIs.
Gene_expression (expressed) of CIs
19) Confidence 0.29 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498201 Disease Relevance 0 Pain Relevance 0
Our objective was to aid in the timely diagnosis of MS in patients who presented with CIS and thus employ the proper treatment early during the course of the disease.


Gene_expression (presented) of CIS associated with multiple sclerosis, syndrome and disease
20) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500255 Disease Relevance 1.74 Pain Relevance 0.45

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