INT128638

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srd5a1) oxidoreductase activity (Srd5a1) endoplasmic reticulum (Srd5a1)
lipid metabolic process (Srd5a1) cytoplasm (Srd5a1)
Anatomy Link Frequency
brain 1
Srd5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 1 97.36 Very High Very High Very High
gABA 6 95.28 Very High Very High Very High
fluoxetine 1 94.24 High High
depression 1 77.64 Quite High
Serotonin 1 63.76 Quite High
antagonist 1 47.24 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 51 94.96 High High
Prostate Cancer 55 84.20 Quite High
Aggression 5 83.72 Quite High
Anxiety Disorder 1 78.48 Quite High
Depression 1 77.64 Quite High
Stress 1 75.00 Quite High
Adhesions 11 43.28 Quite Low
Cancer 36 39.76 Quite Low
Disease 5 37.76 Quite Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This downregulation of 3alpha,5alpha-THP appeared to be associated with the reduction of brain type I 5alpha-reductase mRNA and protein expression.
Transcription (expression) of type I 5alpha-reductase in brain
1) Confidence 0.52 Published 2005 Journal Stress Section Abstract Doc Link 16019600 Disease Relevance 0.47 Pain Relevance 0.39
However, in contrast to their findings, transcripts for AKR1C3, SRD5A1, HSD3B2, AKR1C2, AKR1C1 are not consistently upregulated in the metastatic samples in our study.
Transcription (transcripts) of SRD5A1
2) Confidence 0.33 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.67 Pain Relevance 0

General Comments

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