INT128679

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.78
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
leukocyte 2
neurons 1
hindlimb 1
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 72 100.00 Very High Very High Very High
bradykinin 72 100.00 Very High Very High Very High
sodium channel 2 100.00 Very High Very High Very High
substance P 1 99.92 Very High Very High Very High
Hyperalgesia 2 99.76 Very High Very High Very High
mu opioid receptor 1 98.84 Very High Very High Very High
antagonist 23 98.60 Very High Very High Very High
qutenza 4 98.46 Very High Very High Very High
unmyelinated 1 97.92 Very High Very High Very High
chemokine 80 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 52 99.90 Very High Very High Very High
Nociception 9 99.76 Very High Very High Very High
Hyperalgesia 2 99.76 Very High Very High Very High
Multiple Sclerosis 344 99.00 Very High Very High Very High
Stroke 14 98.56 Very High Very High Very High
Disease 63 98.04 Very High Very High Very High
Pain 9 95.32 Very High Very High Very High
Cv Unclassified Under Development 1 93.52 High High
Ganglion Cysts 4 87.08 High High
Neuropathic Pain 10 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, both leukocyte recruitment and histopathological alterations decreased in B2-/- when compared to the EAE WT.


Negative_regulation (decreased) of B2 in leukocyte associated with multiple sclerosis
1) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.13 Pain Relevance 0.30
Absence of B2 receptor did not modulate TNF-?
Negative_regulation (Absence) of B2 receptor associated with b2 receptor
2) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.02 Pain Relevance 0.35
Recently these results have been consistently contested, leading to the conclusion that the deficiency of bradykinin receptor B2 is not detrimental in experimental stroke [42], and may be beneficial in other pathological conditions.
Negative_regulation (deficiency) of bradykinin receptor B2 associated with stroke and bradykinin
3) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.20 Pain Relevance 0.18
On the other hand, leukocyte adhesion was diminished in B2-/- in comparison with WT mice (Figure 3B).
Negative_regulation (diminished) of B2 in leukocyte associated with adhesions
4) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.15 Pain Relevance 0.32
After damage to peripheral sensory fibers, up-regulated expression of the Ca(v)alpha(2)delta-(1) channel subunit, the Na(v)1.3 sodium channel, and bradykinin (BK) B1 and capsaicin TRPV1 receptors in myelinated neurons contribute to hyperalgesia; while the down-regulation of the Na(v)1.8 sodium channel, B2 receptor, substance P (SP), and even mu-opioid receptors in unmyelinated neurons is responsible for the phenotypic switch in pain transmission.
Negative_regulation (down-regulation) of B2 receptor in neurons associated with pain, qutenza, sodium channel, bradykinin, hyperalgesia, b2 receptor, mu opioid receptor, unmyelinated and substance p
5) Confidence 0.19 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16023729 Disease Relevance 1.26 Pain Relevance 1.59
The blockade of NK1, CGRP, NMDA, beta1-adrenergic, B2 or TRPV1 receptors with selective antagonists partially decreased PMA-induced nociception.
Negative_regulation (blockade) of B2 associated with nociception and antagonist
6) Confidence 0.10 Published 2005 Journal Pain Section Abstract Doc Link 16099101 Disease Relevance 0.67 Pain Relevance 0.39
This was not observed in the ischemic hindlimb of mice lacking B2 receptor (Silvestre et al 2001).


Negative_regulation (lacking) of B2 receptor in hindlimb associated with b2 receptor
7) Confidence 0.01 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.35 Pain Relevance 0.41

General Comments

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