INT128714

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.13
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)
Anatomy Link Frequency
chondrocytes 1
smooth muscle 1
cartilage 1
CII 1
IVD 1
Col2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 73 100.00 Very High Very High Very High
metalloproteinase 3 97.80 Very High Very High Very High
methotrexate 41 96.80 Very High Very High Very High
Inflammation 45 95.12 Very High Very High Very High
rheumatoid arthritis 19 88.16 High High
imagery 13 85.52 High High
Pain 6 85.12 High High
Chronic low back pain 1 72.64 Quite High
cytokine 25 70.32 Quite High
chemokine 3 69.44 Quite High
Disease Link Frequency Relevance Heat
Arthritis 84 100.00 Very High Very High Very High
INFLAMMATION 44 95.12 Very High Very High Very High
Disease 17 94.64 High High
Autoimmune Disease 4 90.52 High High
Rheumatoid Arthritis 19 88.16 High High
Neck Pain 1 85.12 High High
Hypercalcemia 2 77.48 Quite High
Osteoporosis 2 76.84 Quite High
Injury 5 76.16 Quite High
Intervertebral Disk Degeneration 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months.
Transcription (expression) of Col2alpha1 in IVD associated with metalloproteinase
1) Confidence 0.52 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20472983 Disease Relevance 0.23 Pain Relevance 0.21
No collagen II imunostaining was detected in control G1 group of rats 15 and 30 days after surgery and only a faint positive staining was observed on day 45 (Fig. 3a, d and g), although there was fibrous tissue throughout the healing process.
Neg (No) Transcription (detected) of collagen II
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0.10 Pain Relevance 0
CIA: collagen-induced arthritis; CII: type II collagen; CT: computed tomography; ?
Transcription (arthritis) of type II collagen in CII associated with arthritis
3) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.54 Pain Relevance 0.78
Glucosamine alone had no observable stimulatory effect on the transcription of primary cartilage matrix genes, such as aggrecan, collagen type II, or genes involved in glycosaminoglycan synthesis; however, glucosamine proved to be a potent, broad-spectrum inhibitor of IL-1?.
Transcription (transcription) of collagen type II in cartilage
4) Confidence 0.09 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.11
In order to identify chondrocytes, the expression of type II collagen and aggrecan mRNAs and proteins as a chondrogenic markers were determined by RT-PCR and Western blot analysis.
Transcription (expression) of type II collagen in chondrocytes
5) Confidence 0.08 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0.18 Pain Relevance 0.15
The mRNA amount of procollagen alpha2(I), alpha-smooth muscle actin (alpha-SMA), tissue inhibitor of metalloproteinase (TIMP)-1, and TGF-beta1 was also increased by PDGF-BB.
Transcription (amount) of procollagen alpha2 in smooth muscle
6) Confidence 0.03 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0

General Comments

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