INT128717

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.94
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
fibroblast 2
tibia 1
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 15 100.00 Very High Very High Very High
cINOD 6 100.00 Very High Very High Very High
Chronic pancreatitis 2 97.64 Very High Very High Very High
Inflammation 17 93.24 High High
metalloproteinase 14 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fracture Healing 22 99.48 Very High Very High Very High
Tibia Fractures 3 98.96 Very High Very High Very High
Pancreatitis 2 97.64 Very High Very High Very High
Primary Sclerosing Cholangitis 2 95.04 Very High Very High Very High
INFLAMMATION 17 93.24 High High
Rotator Cuff Tears 6 84.64 Quite High
Injury 32 5.00 Very Low Very Low Very Low
Osteoporosis 10 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar changes in TGF-beta1 levels were found at the end of the second and fourth weeks.
Regulation (changes) of TGF-beta1
1) Confidence 0.61 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.60 Pain Relevance 0.22
The effect of various cytokines and osteoinductive growth factors, such as BMP-2, BMP-7, or rhBMP-12, TGF-beta1, TGF-beta2, TGF-beta3, and fibroblast growth factor, have been tested for TBI healing enhancement.
Regulation (effect) of TGF-beta in fibroblast associated with cytokine
2) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2931497 Disease Relevance 0.08 Pain Relevance 0.10
The effect of various cytokines and osteoinductive growth factors, such as BMP-2, BMP-7, or rhBMP-12, TGF-beta1, TGF-beta2, TGF-beta3, and fibroblast growth factor, have been tested for TBI healing enhancement.
Regulation (effect) of TGF-beta in fibroblast associated with cytokine
3) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2931497 Disease Relevance 0.08 Pain Relevance 0.10
In this study, the effects of the NSAID naproxen sodium, G-CSF, and both of them in combination on the TGF-beta1 serum level in rats with tibia fractures were measured and fracture healing was evaluated by histopathologic and radiologic examination.
Regulation (effects) of TGF-beta1 in tibia associated with fracture healing, cinod and tibia fractures
4) Confidence 0.44 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.55 Pain Relevance 0.29
The results point to the negative effect of naproxen sodium on fracture healing is due to its decreasing effect on the level of TGF-beta1, which may be a new possible mechanism.
Regulation (effect) of TGF-beta1 associated with fracture healing
5) Confidence 0.27 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.44 Pain Relevance 0.06
Albeit much effort has been made to study the effects of PDGF and TGF-beta1 on PSCs, their interaction is still unclear, because these cytokines show both differential and synergistic effects as outlined by this study.
Regulation (effects) of TGF-beta1 associated with cytokine
6) Confidence 0.14 Published 2005 Journal Pancreas Section Abstract Doc Link 16025003 Disease Relevance 0.19 Pain Relevance 0.19
CONCLUSION: PDGF-BB augments effects of TGF-beta1 on the mRNA level presumably because of up-regulation of TGF-beta1 synthesis and common signaling pathways of the 2 cytokines.
Regulation (effects) of TGF-beta1
7) Confidence 0.14 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0

General Comments

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