INT128745

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 7 99.98 Very High Very High Very High
Kinase C 1 98.80 Very High Very High Very High
Nerve growth factor 6 89.96 High High
Morphine 8 89.40 High High
ischemia 6 79.48 Quite High
nociceptor 3 78.12 Quite High
Opioid 8 75.00 Quite High
intrathecal 1 73.16 Quite High
Pain 1 69.72 Quite High
MU agonist 2 55.48 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 7 99.98 Very High Very High Very High
Cv Unclassified Under Development 6 79.48 Quite High
Cirrhosis 3 74.80 Quite High
Pain 1 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT3 phosphorylation was also dependent on phosphatidylinositol 3-kinase (PI3K) activation in both tissue and H9C2 cells.
Positive_regulation (dependent) of Positive_regulation (activation) of PI3K
1) Confidence 0.56 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.14 Pain Relevance 0.55
Although inhibitors of kinases downstream of PI3K and PLCgamma[glycogen synthetase kinase 3 (GSK3), calmodulin-dependent protein kinase II (CAMII-K) or protein kinase C (PKC)] do not reduce mechanical hyperalgesia, hyperalgesia induced by activation of PI3K was blocked by ERK/MEK inhibitors, suggesting cross-talk from the PI3K to the ERK/MEK signalling pathway.
Positive_regulation (induced) of Positive_regulation (activation) of PI3K associated with hyperalgesia and kinase c
2) Confidence 0.45 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16026476 Disease Relevance 0.59 Pain Relevance 1.14
STAT3 phosphorylation was also dependent on phosphatidylinositol 3-kinase (PI3K) activation in both tissue and H9C2 cells.
Positive_regulation (dependent) of Positive_regulation (activation) of phosphatidylinositol 3-kinase
3) Confidence 0.40 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.14 Pain Relevance 0.55
Opioid receptor stimulation induced a calcium-dependent protein kinase C alpha (PKC alpha)/extracellular regulated kinase (ERK)/phosphatidylinositol 3-kinase (PI3K) pathway activation that mediated the effect of endogenous opioids on HSC proliferation and collagen synthesis.
Positive_regulation (induced) of Positive_regulation (activation) of PI3K
4) Confidence 0.21 Published 2008 Journal Gut Section Body Doc Link 17989109 Disease Relevance 0.07 Pain Relevance 0

General Comments

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