INT12875

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2008
Negated 1
Speculated 7
Reported most in Abstract
Documents 26
Total Number 32
Disease Relevance 7.51
Pain Relevance 17.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
blood 2
urinary bladder 1
ileum 1
hypothalamic nucleus 1
brain 1
Adra2a (Mus musculus)
Adra2a - H101R (1)
Pain Link Frequency Relevance Heat
agonist 92 100.00 Very High Very High Very High
antagonist 54 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
GABAergic 1 100.00 Very High Very High Very High
Neurotransmitter 8 99.84 Very High Very High Very High
anesthesia 3 99.84 Very High Very High Very High
opioid receptor 2 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 30 99.52 Very High Very High Very High
Impaired Glucose Tolerance 15 99.40 Very High Very High Very High
Shock 6 99.34 Very High Very High Very High
Disorders Of Creatine Metabolism 1 99.20 Very High Very High Very High
Glioma 2 98.70 Very High Very High Very High
Targeted Disruption 10 98.68 Very High Very High Very High
Neuroblastoma 3 98.44 Very High Very High Very High
Natriuresis 6 98.24 Very High Very High Very High
Obesity 18 97.92 Very High Very High Very High
Hypertension 8 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of both alpha2-AR agonists were absent in alpha2a knockout mice, suggesting that the alpha2A-AR mediates the proconvulsant and anticonvulsant effect of alpha2-AR agonists on seizure susceptibility.
Regulation (effects) of alpha2-AR associated with targeted disruption, convulsion, agonist and anticonvulsant
1) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183527 Disease Relevance 0.51 Pain Relevance 0.68
These data help to clarify the inconsistent effects of alpha2-AR agonists on seizure activity.
Regulation (effects) of alpha2-AR associated with convulsion and agonist
2) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183527 Disease Relevance 0.34 Pain Relevance 0.76
These data help to clarify the inconsistent effects of alpha2-AR agonists on seizure activity.
Regulation (effects) of alpha2-AR associated with convulsion and agonist
3) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183527 Disease Relevance 0.34 Pain Relevance 0.76
We investigated the effect of alpha2-adrenoceptor antagonists on the suppressive action of 5-HT2 receptor antagonists in mice pretreated with the noradrenaline toxin 6-hydroxydopamine (6-OHDA) or the 5-HT synthesis inhibitor p-chlorophenylalanine (p-CPA).
Spec (investigated) Regulation (effect) of alpha2-adrenoceptor in CPA associated with antagonist and noradrenaline
4) Confidence 0.42 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077577 Disease Relevance 0 Pain Relevance 0.48
The aim of the present study was to investigate the dose-dependence of the selective alpha 2-receptor agonists UK 14,304, dexmedetomidine and clonidine on these alpha 2-adrenoceptors in the airway of guinea-pigs in vivo.
Spec (investigate) Regulation (dose-dependence) of alpha 2-receptor associated with addiction, agonist and clonidine
5) Confidence 0.42 Published 1991 Journal Acta Physiol. Scand. Section Abstract Doc Link 1678910 Disease Relevance 0 Pain Relevance 0.27
Influence of some alpha 2-receptor agonists and antagonists on the excitatory non-adrenergic, non-cholinergic neurotransmission in the airways of guinea-pigs in vivo.
Regulation (Influence) of alpha 2-receptor associated with antagonist and agonist
6) Confidence 0.42 Published 1991 Journal Acta Physiol. Scand. Section Title Doc Link 1678910 Disease Relevance 0 Pain Relevance 0.25
The mechanism of the withdrawal reaction may involve agonist-induced down regulation of alpha 2-adrenergic receptor affinity, number, or both.
Regulation (regulation) of alpha 2-adrenergic associated with agonist and withdrawal
7) Confidence 0.40 Published 1984 Journal Hypertension Section Abstract Doc Link 6150002 Disease Relevance 0.08 Pain Relevance 0.60
However, because of the complexity of multiple alpha2-AR subtypes and their distribution, the exact role of this receptor in modulating seizure activity is not clear. alpha2A- and alpha2C-ARs function as both autoreceptors (presynaptic) on noradrenergic neurons, where they regulate norepinephrine (NE) release, and as postsynaptic receptors on neurons that receive noradrenergic innervation, where they regulate the release of other neurotransmitters (heteroreceptor).
Regulation (regulate) of alpha2A in neurons associated with neurotransmitter and convulsion
8) Confidence 0.39 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183527 Disease Relevance 0.42 Pain Relevance 0.49
Consequently, when studying the effects of yohimbine and other alpha 2-adrenoceptor antagonists on noradrenergic neurotransmission, the possibility of non-specific effects should be taken into consideration, particularly in the high concentrations range.
Regulation (effects) of 2-adrenoceptor associated with antagonist
9) Confidence 0.39 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2990943 Disease Relevance 0 Pain Relevance 0.65
These experiments demonstrate that in the anterior hypothalamic nucleus of the mouse (and probably in the rat) alpha2A-adrenergic receptors mediate both sympathoinhibitory responses to alpha2-adrenergic receptor agonists and the action of atrial natriuretic peptide.
Regulation (responses) of alpha2-adrenergic in hypothalamic nucleus associated with natriuresis and agonist
10) Confidence 0.39 Published 2003 Journal Hypertension Section Abstract Doc Link 12623961 Disease Relevance 0.59 Pain Relevance 0.19
The threshold of seizures induced by electroconvulsive shock (ECS) was determined in mice and the effects of alpha 2-adrenoceptor antagonists (yohimbine, rauwolscine, idazoxan), alpha 2-adrenoceptor agonists (clonidine, B-HT 920), serotonin antagonists (methysergide, metergoline) and a serotonin agonist (quipazine) were studied.
Regulation (effects) of 2-adrenoceptor associated with convulsion, antagonist, shock, agonist, serotonin and clonidine
11) Confidence 0.35 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2868485 Disease Relevance 0.48 Pain Relevance 0.63
The threshold of seizures induced by electroconvulsive shock (ECS) was determined in mice and the effects of alpha 2-adrenoceptor antagonists (yohimbine, rauwolscine, idazoxan), alpha 2-adrenoceptor agonists (clonidine, B-HT 920), serotonin antagonists (methysergide, metergoline) and a serotonin agonist (quipazine) were studied.
Regulation (effects) of 2-adrenoceptor associated with convulsion, antagonist, shock, agonist, serotonin and clonidine
12) Confidence 0.35 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2868485 Disease Relevance 0.50 Pain Relevance 0.71
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Regulation ([Selectivity) of alpha 2-adrenergic associated with agonist
13) Confidence 0.29 Published 1989 Journal Arch Mal Coeur Vaiss Section Title Doc Link 2573323 Disease Relevance 0 Pain Relevance 0.20
We investigated the effects of the adrenergic alpha2-receptor agonists clonidine, oxymetazoline and tizanidine on bladder contractions induced by infusing fluid into the bladders of conscious male rats.
Spec (investigated) Regulation (effects) of alpha2-receptor in bladders associated with agonist and clonidine
14) Confidence 0.27 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11202609 Disease Relevance 0.13 Pain Relevance 0.50
Effects of adrenergic alpha2-receptor agonists on urinary bladder contraction in conscious rats.
Regulation (Effects) of alpha2-receptor in urinary bladder associated with agonist
15) Confidence 0.27 Published 2000 Journal Jpn. J. Pharmacol. Section Title Doc Link 11202609 Disease Relevance 0.22 Pain Relevance 0.64
This study examines the effects of a relatively selective alpha 2-adrenoceptor antagonist, 8-(L-piperazinyl)imado-[1,2-alpha] pyrazine (compound A), and the preferential alpha 2-agonist clonidine on blood glucose, glucose tolerance, and plasma insulin levels in the C57BL/6J ob/ob mouse and its lean littermate.
Spec (examines) Regulation (effects) of 2-adrenoceptor in blood associated with antagonist, obesity, tolerance, agonist, impaired glucose tolerance and clonidine
16) Confidence 0.20 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.61 Pain Relevance 0.58
Yohimbine transiently reversed the effect of lidamidine. alpha 1-Adrenergic or dopaminergic antagonists did not reverse the effect of lidamidine, suggesting that it may affect alpha 2-adrenergic receptors.
Spec (may) Regulation (affect) of alpha 2-adrenergic associated with antagonist
17) Confidence 0.18 Published 1982 Journal Gastroenterology Section Abstract Doc Link 6121738 Disease Relevance 0 Pain Relevance 0.49
Thus, combination therapies targeting the alpha2aAR and opioid receptors may prove useful in maximizing the analgesic efficacy of opioids while decreasing total dose requirements.
Regulation (targeting) of alpha2aAR associated with analgesic, opioid receptor and opioid
18) Confidence 0.15 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9278550 Disease Relevance 0 Pain Relevance 1.85
Concomitant treatment with a potent somatostatin analog to inhibit insulin release blocked the effects of the alpha 2-adrenoceptor antagonist, compound A.
Regulation (effects) of 2-adrenoceptor associated with antagonist and somatostatin
19) Confidence 0.15 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.90 Pain Relevance 0.89
Effects of an alpha 2-adrenoceptor antagonist on glucose tolerance in the genetically obese mouse (C57BL/6J ob/ob).
Regulation (Effects) of 2-adrenoceptor associated with antagonist, obesity, tolerance and impaired glucose tolerance
20) Confidence 0.15 Published 1990 Journal Metab. Clin. Exp. Section Title Doc Link 1970847 Disease Relevance 0.81 Pain Relevance 0.73

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