INT128752

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.80
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
bridge 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 43 99.70 Very High Very High Very High
Arthritis 169 99.60 Very High Very High Very High
rheumatoid arthritis 41 94.96 High High
agonist 59 92.48 High High
antagonist 20 91.24 High High
dexamethasone 10 89.36 High High
Inflammation 136 86.32 High High
Pain 3 85.64 High High
Glutamate receptor 21 81.28 Quite High
Bioavailability 3 80.72 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 292 100.00 Very High Very High Very High
Hypersensitivity 53 100.00 Very High Very High Very High
Anaerobic Bacterial Infections 11 100.00 Very High Very High Very High
Experimental Arthritis 103 99.60 Very High Very High Very High
Stress 21 99.56 Very High Very High Very High
Pressure And Volume Under Development 30 96.48 Very High Very High Very High
Multiple Sclerosis 235 96.08 Very High Very High Very High
Rheumatoid Arthritis 41 94.96 High High
Systemic Lupus Erythematosus 28 91.84 High High
Disease 223 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CH4893237 reduced the amount of ER at the protein level and impaired the nuclear accumulation of ER, indicating an orally active pure anti-estrogen.
Negative_regulation (impaired) of Localization (accumulation) of ER
1) Confidence 0.43 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.39 Pain Relevance 0.29
ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?
Negative_regulation (inhibits) of Localization (response) of ERA-63 associated with hypersensitivity and anaerobic bacterial infections
2) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.66 Pain Relevance 0.22
ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ER?
Negative_regulation (inhibits) of Localization (response) of ER associated with hypersensitivity and anaerobic bacterial infections
3) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.66 Pain Relevance 0.22
Oestrogen treatment is clearly protective in collagen induced arthritis (CIA) and pharmacologic blocking of both nuclear ER?
Negative_regulation (blocking) of Localization (nuclear) of ER associated with experimental arthritis and arthritis
4) Confidence 0.30 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.44 Pain Relevance 0.18
Following rinsing in PBS, samples were blocked with normal goat serum (Vector Labs, Peterborough, UK) then incubated overnight at 4°C with the previously validated rabbit polyclonal ER?
Negative_regulation (previously) of Localization (validated) of ER
5) Confidence 0.29 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.07 Pain Relevance 0
Both depletion and increase in intraluminal ER Ca2+ concentration induce ER stress and compromise proteostasis (LaFerla, 2002; Paschen and Mengesdorf, 2005).
Negative_regulation (depletion) of Localization (concentration) of ER associated with stress
6) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.10 Pain Relevance 0.09
activity, and this in conjunction with the downregulation of IP3R, predicts a reduction in calcium release from the ER.
Negative_regulation (reduction) of Localization (release) of ER
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.27 Pain Relevance 0.04
In fact, the mutations that reduced glutamate affinity also impaired ER export, whereas a mutant that facilitated ligand-induced conformational change had an accelerated ER export.
Negative_regulation (impaired) of Localization (export) of ER associated with glutamate
8) Confidence 0.04 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.20
Interestingly, the single disulfide bridge of TcCRT is reduced when the protein is located in the cytosol, a likely consequence of its reduction in the ER previous to retrotranslocation.
Negative_regulation (reduction) of Localization (retrotranslocation) of ER in bridge
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Although we have not investigated possible links between anoxia and ER function in any detail, it is notable that the anoxia-induced ER Ca2+ release persists in the presence of FCCP.
Negative_regulation (persists) of Localization (release) of ER associated with hypoxia
10) Confidence 0.02 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.58 Pain Relevance 0
Moreover, the observation that ryanodine prevented anoxia-induced release of Ca2+ from the ER suggests that Ca2+ efflux via ryanodine receptors plays an important role in mediating this slow ER Ca2+ release.
Negative_regulation (prevented) of Localization (release) of ER associated with hypoxia
11) Confidence 0.02 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.63 Pain Relevance 0

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