INT128753

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.76
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCF-7 4
ZR-75-1 1
BT-474 1
MDA-MB-231 1
Mmv7 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 82.32 Quite High
cINOD 4 79.96 Quite High
Bioavailability 5 79.92 Quite High
Inflammation 3 77.40 Quite High
Pain 4 76.72 Quite High
COX-2 inhibitor 2 75.00 Quite High
agonist 7 69.60 Quite High
Dismenorea 1 51.24 Quite High
cva 7 34.44 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 30 100.00 Very High Very High Very High
Breast Cancer 77 99.36 Very High Very High Very High
Cancer 47 89.28 High High
INFLAMMATION 5 79.40 Quite High
Pain 4 76.72 Quite High
Immunotherapy Of Cancer 5 71.04 Quite High
Endometriosis (extended) 16 64.84 Quite High
Osteoporosis 6 59.52 Quite High
Cramps 1 54.48 Quite High
Weight Gain 3 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flow cytometry demonstrates that this increase in cell number is not associated with dramatic changes in cell cycle (Table 1) but is associated with a significant decrease in apoptosis in MCF-7CLU compared to the parental MCF-7 cells (Table 2).
Negative_regulation (decrease) of MCF-7CLU in MCF-7 associated with apoptosis
1) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.25 Pain Relevance 0
Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.
Negative_regulation (inhibition) of MCF-7 in BT-474
2) Confidence 0.16 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26
Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.
Negative_regulation (inhibition) of MCF-7 in MCF-7
3) Confidence 0.05 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26
Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.
Negative_regulation (inhibition) of MCF-7 in ZR-75-1
4) Confidence 0.05 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26
Indeed the metabolite seems to be a more potent inhibitor of MCF-7 cells than both tamoxifen and arzoxifene itself (Freddie et al. 2004).
Negative_regulation (inhibitor) of MCF-7 in MCF-7
5) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.64 Pain Relevance 0.09
However, it needs much higher concentrations to inhibit MCF-7 and MDA-MB-231 breast cancer cell growth with IC(50) at 22.1microM and 19.6microM, respectively.
Negative_regulation (inhibit) of MCF-7 in MDA-MB-231 associated with breast cancer
6) Confidence 0.01 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428334 Disease Relevance 0.92 Pain Relevance 0.20
However, it needs much higher concentrations to inhibit MCF-7 and MDA-MB-231 breast cancer cell growth with IC(50) at 22.1microM and 19.6microM, respectively.
Negative_regulation (inhibit) of MCF-7 in MCF-7 associated with breast cancer
7) Confidence 0.00 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428334 Disease Relevance 0.92 Pain Relevance 0.20

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