INT128753

Context Info Confidence 0.27 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 3.76 Pain Relevance 1.26

Anatomy Link Frequency MCF-7 4 ZR-75-1 1 BT-474 1 MDA-MB-231 1 Mmv7 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 5 82.32 cINOD 4 79.96 Bioavailability 5 79.92 Inflammation 3 77.40 Pain 4 76.72 COX-2 inhibitor 2 75.00 agonist 7 69.60 Dismenorea 1 51.24 cva 7 34.44 cytokine 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 30 100.00 Breast Cancer 77 99.36 Cancer 47 89.28 INFLAMMATION 5 79.40 Pain 4 76.72 Immunotherapy Of Cancer 5 71.04 Endometriosis (extended) 16 64.84 Osteoporosis 6 59.52 Cramps 1 54.48 Weight Gain 3 51.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Flow cytometry demonstrates that this increase in cell number is not associated with dramatic changes in cell cycle (Table 1) but is associated with a significant decrease in apoptosis in MCF-7CLU compared to the parental MCF-7 cells (Table 2).

Negative_regulation (decrease) of MCF-7CLU in MCF-7 associated with apoptosis

1) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.25 Pain Relevance 0

Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.

Negative_regulation (inhibition) of MCF-7 in BT-474

2) Confidence 0.16 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26

Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.

Negative_regulation (inhibition) of MCF-7 in MCF-7

3) Confidence 0.05 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26

Furthermore, CH4893237 inhibited the estrogen-stimulated proliferation of MCF-7, ZR-75-1 and BT-474 cells, and caused a marked growth inhibition of the MCF-7 xenograft in vivo.

Negative_regulation (inhibition) of MCF-7 in ZR-75-1

4) Confidence 0.05 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.34 Pain Relevance 0.26

Indeed the metabolite seems to be a more potent inhibitor of MCF-7 cells than both tamoxifen and arzoxifene itself (Freddie et al. 2004).

Negative_regulation (inhibitor) of MCF-7 in MCF-7

5) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.64 Pain Relevance 0.09

However, it needs much higher concentrations to inhibit MCF-7 and MDA-MB-231 breast cancer cell growth with IC(50) at 22.1microM and 19.6microM, respectively.

Negative_regulation (inhibit) of MCF-7 in MDA-MB-231 associated with breast cancer

6) Confidence 0.01 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428334 Disease Relevance 0.92 Pain Relevance 0.20

However, it needs much higher concentrations to inhibit MCF-7 and MDA-MB-231 breast cancer cell growth with IC(50) at 22.1microM and 19.6microM, respectively.

Negative_regulation (inhibit) of MCF-7 in MCF-7 associated with breast cancer

7) Confidence 0.00 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19428334 Disease Relevance 0.92 Pain Relevance 0.20

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