INT128756

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Esr1, Foxc1) cytoplasm (Esr1, Foxc1) nucleus (Esr1, Foxc1)
transcription factor binding (Esr1, Foxc1) enzyme binding (Esr1) protein complex (Esr1)
Anatomy Link Frequency
uterine 1
Esr1 (Mus musculus)
Foxc1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 99.96 Very High Very High Very High
Inflammation 1 95.00 High High
Pain 1 94.32 High High
Bioavailability 1 89.40 High High
agonist 2 87.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 95.00 High High
Pain 1 94.32 High High
Endometriosis (extended) 1 82.44 Quite High
Cancer 1 81.28 Quite High
Breast Cancer 2 77.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In search of a patient- friendly pure anti-estrogen, we screened and identified an ER antagonist, CH4893237, which bound to ER with an IC50 value of 1.4 muM and, by oral administration, inhibited estrogen-stimulated uterine growth in ovariectomized mice.
ER Binding (bound) of CH4893237 in uterine associated with antagonist
1) Confidence 0.01 Published 2005 Journal Anticancer Drugs Section Abstract Doc Link 16027525 Disease Relevance 0.43 Pain Relevance 0.32

General Comments

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