INT128769

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.85
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 2
T cell 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 1 99.76 Very High Very High Very High
antagonist 27 99.68 Very High Very High Very High
Inflammation 116 99.36 Very High Very High Very High
cytokine 236 98.84 Very High Very High Very High
antidepressant 1 98.38 Very High Very High Very High
agonist 12 97.68 Very High Very High Very High
chemokine 26 84.48 Quite High
psoriasis 14 75.44 Quite High
tolerance 26 73.84 Quite High
Central nervous system 24 64.32 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 1 99.76 Very High Very High Very High
INFLAMMATION 139 99.36 Very High Very High Very High
Chlamydia Infection 67 99.36 Very High Very High Very High
Influenza Virus Infection 2 98.76 Very High Very High Very High
Herpes Simplex Virus 4 98.24 Very High Very High Very High
Renal Disease 62 97.20 Very High Very High Very High
Body Weight 2 96.96 Very High Very High Very High
Disease 254 96.80 Very High Very High Very High
Lifespan 7 94.72 High High
Systemic Lupus Erythematosus 252 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although not statistically significant, patients scheduled to receive IFN-?
Negative_regulation (scheduled) of Localization (receive) of IFN
1) Confidence 0.24 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936304 Disease Relevance 0.70 Pain Relevance 0
Furthermore, an antagonist against TLR7/9 inhibited type I IFN secretion from pDCs activated with live influenza or herpes simplex virus as well as immune complexes (R Coffman).
Negative_regulation (inhibited) of Localization (secretion) of IFN associated with herpes simplex virus, influenza virus infection and antagonist
2) Confidence 0.11 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.45 Pain Relevance 0.44
This gene mutation abrogates type I IFN secretion as well as pro-inflammatory cytokine production upon TLR agonist ligation.
Negative_regulation (abrogates) of Localization (secretion) of IFN associated with inflammation, agonist and cytokine
3) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.94 Pain Relevance 0.18
Importantly, many of these factors were localized to microglia and their downregulation in the absence of IFN-?
Negative_regulation (downregulation) of Neg (absence) Localization (absence) of IFN in microglia
4) Confidence 0.05 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.46 Pain Relevance 0.20
Clinical improvement was accompanied by a significant reduction in anti-dsDNA autoantibody production and by significantly reduced secretion of IFN-?
Negative_regulation (reduced) of Localization (secretion) of IFN
5) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.88 Pain Relevance 0.11
Clinical improvement was accompanied by a significant reduction in anti-dsDNA autoantibody production and by significantly reduced secretion of IFN-?
Negative_regulation (reduction) of Localization (secretion) of IFN
6) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.90 Pain Relevance 0.11
CCL5 blockade diminished these cellular responses along with C. muridarum-specific CD4+ T cell secretion of IFN-?
Negative_regulation (diminished) of Localization (secretion) of IFN in T cell
7) Confidence 0.02 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.63 Pain Relevance 0.11
In particular, according to recent evidences, antidepressants seem to exert beneficial effects in experimental autoimmune neuritis in rats by decreasing IFN- beta release or augmenting NK activity in depressed patients.
Negative_regulation (decreasing) of Localization (release) of IFN associated with antidepressant, experimental autoimmune neuritis and neuritis
8) Confidence 0.02 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16029148 Disease Relevance 0.89 Pain Relevance 0.20

General Comments

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