INT128773

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.41
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6b)
Anatomy Link Frequency
eye 2
neurons 2
lung 2
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 9 98.44 Very High Very High Very High
antinociception 6 98.08 Very High Very High Very High
dorsal root ganglion 6 97.96 Very High Very High Very High
Nav1.7 1 97.24 Very High Very High Very High
Nav1.6 1 96.80 Very High Very High Very High
antagonist 2 93.76 High High
Sciatic nerve 1 92.80 High High
unmyelinated 1 91.84 High High
Nav1.9 4 89.80 High High
nav1.8 2 89.36 High High
Disease Link Frequency Relevance Heat
Nociception 1 98.44 Very High Very High Very High
Ganglion Cysts 8 97.96 Very High Very High Very High
Hypertension 54 95.16 Very High Very High Very High
Disease 14 70.36 Quite High
Pulmonary Disease 10 69.40 Quite High
Sickle Cell Anemia 2 64.00 Quite High
Hyperlipidemia 2 62.72 Quite High
Muscular Dystrophy 2 62.08 Quite High
Hypopigmentation 2 60.92 Quite High
Syndrome 2 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently demonstrated that the rd1 mutation can be corrected in vitro by gene repair in non-ocular cell lines using locked nucleic acids (LNAs) and phosphorothioate ODNs designed to correct the point mutation in the ?
Regulation (corrected) of Gene_expression (mutation) of rd1
1) Confidence 0.45 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0.37 Pain Relevance 0
M WTS ODN-treated rd1 eye sections, a positive fluorescent signal for ?
Regulation (treated) of Gene_expression (sections) of rd1 in eye
2) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765472 Disease Relevance 0 Pain Relevance 0
Possible changes in the expression of KOP-r were investigated in tolerant mice to nicotine antinociception by using autoradiography of [3H]CI-977 binding.
Spec (Possible) Regulation (changes) of Gene_expression (expression) of KOP-r associated with antinociception and nicotine
3) Confidence 0.12 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18221370 Disease Relevance 0 Pain Relevance 1.25
No significant differences in GSNO-R protein expression were seen in the lung homogenates of adult male and female animals.


Neg (No) Regulation (differences) of Gene_expression (expression) of GSNO-R in lung
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.05 Pain Relevance 0
Increased activity was not due to changes in GSNO-R expression, but correlated with GSNO-R S-nitrosylation: females were greater than males.
Regulation (changes) of Gene_expression (expression) of GSNO-R
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.45 Pain Relevance 0
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons; this regulation could modulate the membrane properties and excitability of these neurons.
Neg (not) Regulation (regulating) of Gene_expression (expression) of TTX-R in neurons associated with nociception and dorsal root ganglion
6) Confidence 0.01 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.54 Pain Relevance 1.25

General Comments

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