INT128774

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) signal transduction (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
sciatic nerves 2
neurons 2
Ednrb (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.6 2 99.60 Very High Very High Very High
Sciatic nerve 2 99.30 Very High Very High Very High
Nav1.7 2 99.16 Very High Very High Very High
unmyelinated 2 98.82 Very High Very High Very High
dorsal root ganglion 12 98.52 Very High Very High Very High
Nav1.9 8 97.80 Very High Very High Very High
nav1.8 4 97.58 Very High Very High Very High
sodium channel 10 84.24 Quite High
tetrodotoxin 6 77.28 Quite High
nav1.3 2 47.96 Quite Low
Disease Link Frequency Relevance Heat
Nociception 2 99.00 Very High Very High Very High
Ganglion Cysts 12 98.52 Very High Very High Very High
Repression 1 84.32 Quite High
INFLAMMATION 21 26.96 Quite Low
Mycobacterial Infection 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 1 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gpr109b/PUMA-G, Fpr1, Ccrl2 and Ednrb) ([12-16], Sweet et al, unpublished data), regulated expression of others has not been widely studied.
Regulation (regulated) of Gene_expression (expression) of Ednrb
1) Confidence 0.46 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons; this regulation could modulate the membrane properties and excitability of these neurons.
Neg (not) Regulation (regulating) of Gene_expression (expression) of TTX-S in neurons associated with nociception and dorsal root ganglion
2) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.54 Pain Relevance 1.25
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Neg (no) Regulation (changes) of Gene_expression (expression) of TTX-S in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
3) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.37 Pain Relevance 1.31

General Comments

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