INT128776

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6b) cell adhesion (Cntn1) plasma membrane (Cntn1)
Anatomy Link Frequency
neurons 2
Cntn1 (Mus musculus)
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 1 98.60 Very High Very High Very High
Nav1.6 1 98.16 Very High Very High Very High
dorsal root ganglion 6 97.96 Very High Very High Very High
Sciatic nerve 1 94.16 High High
unmyelinated 1 93.20 High High
Nav1.9 4 91.16 High High
nav1.8 2 90.72 High High
sodium channel 5 79.80 Quite High
tetrodotoxin 3 75.00 Quite High
nav1.3 1 43.52 Quite Low
Disease Link Frequency Relevance Heat
Nociception 1 98.44 Very High Very High Very High
Ganglion Cysts 6 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons; this regulation could modulate the membrane properties and excitability of these neurons.
contactin Positive_regulation (role) of Gene_expression (expression) of TTX-R in neurons associated with nociception and dorsal root ganglion
1) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.55 Pain Relevance 1.26

General Comments

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