INT128793

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 10.69
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBB) transport (HBB)
Anatomy Link Frequency
nipple 2
blood 1
hematopoietic stem cells 1
RBC 1
HBB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 89.40 High High
dexamethasone 1 86.00 High High
Pain 17 78.84 Quite High
palliative 1 72.04 Quite High
Duloxetine 2 71.12 Quite High
anesthesia 6 64.24 Quite High
Paracetamol 2 57.68 Quite High
alcohol 11 56.84 Quite High
cva 18 48.56 Quite Low
Versed 2 47.52 Quite Low
Disease Link Frequency Relevance Heat
Thalassemia 570 99.48 Very High Very High Very High
Colon Cancer 30 99.36 Very High Very High Very High
Hematological Disease 16 99.28 Very High Very High Very High
Cancer 218 99.24 Very High Very High Very High
Rare Diseases 1 99.10 Very High Very High Very High
Syndrome 9 98.44 Very High Very High Very High
Sickle Cell Trait 56 97.08 Very High Very High Very High
Anaemia 81 96.88 Very High Very High Very High
Stress 27 96.56 Very High Very High Very High
Frailty 2 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 37-year-old man with beta-thalassemia intermedia (betaTI), a rare disease caused by partial or complete deficiency of beta-globin chain synthesis, fell into a hemolytic crisis.
Gene_expression (synthesis) of beta-globin associated with rare diseases and thalassemia
1) Confidence 0.78 Published 2005 Journal J Anesth Section Abstract Doc Link 16032456 Disease Relevance 0.69 Pain Relevance 0.06
Our clinical trial at Memorial Sloan-Kettering Cancer Center builds on a 20-year long investigation to develop an erythroid-specific vector to regulate beta-globin transgene expression in the progeny of transduced hematopoietic stem cells.
Gene_expression (expression) of beta-globin in hematopoietic stem cells associated with cancer
2) Confidence 0.75 Published 2009 Journal Hemoglobin Section Abstract Doc Link 20001625 Disease Relevance 0.59 Pain Relevance 0.07
The procedure was optimized to different TMAC washing temperatures for the different probes, reaching an optimum specificity of 62°C and 65°C for HbB and G6PD probes, respectively.
Gene_expression (probes) of HbB
3) Confidence 0.57 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0
The most prevalent polymorphic variants of the HbB gene consist of the normal gene (HbA) in which SNPs in the same amino acid position give rise to either the sickle haemoglobin S, (HbS, Glu to Val at c6 (E6V)) or the common west-African haemoglobin C (HbC, Glu to Lys at c6 (E6K)).
Gene_expression (consist) of HbB
4) Confidence 0.57 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0.53 Pain Relevance 0.04
We found that four of the five investigated genes, HBA, HBB, HBE and HEBP1, showed decreased expression levels in foxes selected for tameness compared to non-selected farm foxes.
Gene_expression (expression) of HBB
5) Confidence 0.47 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
These dog mRNA species corresponded to five predicted dog genes, including four hemoglobins, namely, the beta (HBB) and epsilon (HBE) chains (located on canine chromosome 21), the alpha (HBA) and zeta (HBZ) chains (ESTs that mapped to canine chromosome 6), and the heme binding protein 1 gene (HEBP1) (located on canine chromosome 27).
Gene_expression (corresponded) of HBB
6) Confidence 0.41 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
Thus to evaluate the potential effect of blood perfusion on HBE and HEBP1 expression levels, we assumed that the average HBA and HBB levels (HB) could represent the maximum effect of blood perfusion caused by e.g. a systemic stress response.
Gene_expression (levels) of HBB in blood associated with stress
7) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.10 Pain Relevance 0
Alpha2-HS-glycoprotein was under-expressed in nipple aspirate fluid from tumor-bearing breasts, while lipophilin B, beta-globin, hemopexin, and vitamin D-binding protein precursor were over-expressed [10].


Gene_expression (-) of beta-globin in nipple associated with cancer
8) Confidence 0.09 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.96 Pain Relevance 0
Alpha2-HS-glycoprotein was under-expressed in nipple aspirate fluid from tumor-bearing breasts, while lipophilin B, beta-globin, hemopexin, and vitamin D-binding protein precursor were over-expressed [10].


Gene_expression (expressed) of beta-globin in nipple associated with cancer
9) Confidence 0.09 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 0.96 Pain Relevance 0
hemoglobin chain replaces glutamic acid with valine and produces the so-called abnormal hemoglobin type HbS (the normal type is HbA).
Gene_expression (produces) of hemoglobin type HbS
10) Confidence 0.08 Published 2005 Journal BMC Med Educ Section Body Doc Link PMC1142319 Disease Relevance 0.35 Pain Relevance 0
Hemoglobin electrophoresis indicated HbA 57.3% and HbS 42.7%.
Gene_expression (electrophoresis) of Hemoglobin
11) Confidence 0.07 Published 2008 Journal Cases J Section Body Doc Link PMC2628646 Disease Relevance 0.32 Pain Relevance 0
Work-up included a hemoglobin (Hb) electrophoresis which demonstrated HbS 34.8%, HbA 60.5%, and HbA2 4.2%, consistent with sickle cell trait.


Gene_expression (electrophoresis) of hemoglobin associated with sickle cell trait
12) Confidence 0.07 Published 2008 Journal Cases J Section Body Doc Link PMC2628646 Disease Relevance 0.85 Pain Relevance 0.20
The beta globin gene mutations cause a reduced or absent production of beta globin chains.
Neg (absent) Gene_expression (production) of beta globin
13) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.15 Pain Relevance 0
Beta-thalassemia syndromes are a group of hereditary blood disorders characterized by reduced or absent beta globin chain synthesis, resulting in reduced Hb in red blood cells (RBC), decreased RBC production and anemia.
Neg (absent) Gene_expression (synthesis) of beta globin in RBC associated with hematological disease, anaemia, syndrome and thalassemia
14) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 2.63 Pain Relevance 0
In contrast with the classical recessive forms of beta-thalassemia, which lead to a reduced production of normal beta globin chains, some rare mutations result in the synthesis of extremely unstable beta globin variants which precipitate in erythroid precursors causing ineffective erythropoiesis.
Gene_expression (production) of beta globin associated with thalassemia
15) Confidence 0.05 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.48 Pain Relevance 0
On day 11, lysates were prepared for high performance liquid chromatography (HPLC) analysis of globin chain expression and DNA was isolated for bisulfite sequence analysis.


Gene_expression (expression) of globin chain
16) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.07 Pain Relevance 0.04

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