INT128794

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.98
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBB) transport (HBB)
Anatomy Link Frequency
RBC 2
HBB (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 64.24 Quite High
cva 12 48.88 Quite Low
isoflurane 1 41.68 Quite Low
depression 4 36.08 Quite Low
Spinal cord 3 28.36 Quite Low
fibrosis 15 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Parenteral administration 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 563 99.64 Very High Very High Very High
Hematological Disease 15 99.64 Very High Very High Very High
Rare Diseases 1 99.38 Very High Very High Very High
Syndrome 6 98.80 Very High Very High Very High
Anaemia 79 96.88 Very High Very High Very High
Thrombocytopenia 9 88.68 High High
Calcification 3 84.16 Quite High
Disease 42 83.76 Quite High
Hepatotoxicity 1 82.88 Quite High
Mixed Connective Tissue Disorder 3 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 37-year-old man with beta-thalassemia intermedia (betaTI), a rare disease caused by partial or complete deficiency of beta-globin chain synthesis, fell into a hemolytic crisis.
Spec (partial) Negative_regulation (deficiency) of Gene_expression (synthesis) of beta-globin associated with rare diseases and thalassemia
1) Confidence 0.59 Published 2005 Journal J Anesth Section Abstract Doc Link 16032456 Disease Relevance 0.69 Pain Relevance 0.06
In contrast with the classical recessive forms of beta-thalassemia, which lead to a reduced production of normal beta globin chains, some rare mutations result in the synthesis of extremely unstable beta globin variants which precipitate in erythroid precursors causing ineffective erythropoiesis.
Negative_regulation (reduced) of Gene_expression (production) of beta globin associated with thalassemia
2) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.48 Pain Relevance 0
The beta globin gene mutations cause a reduced or absent production of beta globin chains.
Negative_regulation (reduced) of Neg (absent) Gene_expression (production) of beta globin
3) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.16 Pain Relevance 0
Beta-thalassemia syndromes are a group of hereditary blood disorders characterized by reduced or absent beta globin chain synthesis, resulting in reduced Hb in red blood cells (RBC), decreased RBC production and anemia.
Negative_regulation (reduced) of Neg (absent) Gene_expression (synthesis) of beta globin in RBC associated with hematological disease, anaemia, syndrome and thalassemia
4) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 2.64 Pain Relevance 0

General Comments

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